AI Article Synopsis
- Medroxyprogesterone acetate (MPA) is a progestin commonly used in feminizing hormone therapy, but its effects on transgender individuals had not been previously studied.
- A study involving 290 transwomen showed that MPA use led to lower testosterone levels while not significantly affecting estrogen levels; most participants reported positive effects on breast development and body hair.
- The findings suggest minimal side effects associated with MPA and a decrease in testosterone, indicating its effectiveness in promoting feminization, but more research is necessary to validate these results.
Article Abstract
Context: Medroxyprogesterone acetate (MPA) is a widely used progestin in feminizing hormone therapy. However, the side effects and hormonal changes elicited by this drug have never been investigated in the transgender population.
Objective: We evaluated the incidence of self-reported effects among transwomen using MPA and this drug's impact on hormonal and metabolic parameters.
Design, Setting, And Participants: We retrospectively collected data from 290 follow-up visits (FUVs) of transwomen treated at Rhode Island Hospital from January 2011 to July 2018 (mean duration of therapy 3.4 ± 1.7 years). FUVs followed regimens of estradiol (E) and spironolactone, with MPA (n = 102) or without MPA (n = 188).
Main Outcome Measures: We assessed the incidence of self-reported effects after MPA treatment. We also compared blood levels of E, testosterone, and various laboratory parameters between MPA and non-MPA groups.
Results: Mean weighted E level was 211 ± 57 pg/mL after MPA treatment and 210 ± 31 pg/mL otherwise; this difference was nonsignificant [t(274) = 0.143, P = 0.886]. Mean weighted testosterone level was 79 ± 18 ng/dL after MPA treatment and 215 ± 29 ng/dL otherwise; testosterone levels were significantly lower in the MPA group [t(122) = 32.4, P < 0.001]. There were minimal changes in other laboratory parameters. Of 39 patients receiving MPA, 26 reported improved breast development and 11 reported decreased facial hair. Five patients experienced mood swings on MPA.
Conclusions: In our cohort of transwomen, we found minimal side effects, unchanged E levels, and a decline in testosterone associated with MPA, outcomes consistent with feminization. Prospective studies are needed to confirm our findings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1210/jc.2018-02253 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Patellofemoral mechanics after uniplane open wedge high tibial osteotomy is superior to those after biplane open wedge high tibial osteotomy.
BMC Musculoskelet Disord
January 2025
Department of Orthopedic Surgery, The 3rd Hospital of Hebei Medical University, Hebei, Shijiazhuang, 050051, P.R. China.
Background: It is known that open wedge high tibial osteotomy (OWHTO) may lead to progression of patellofemoral degeneration due to descent of the patellar height. However, the difference in patellofemoral joint (PFJ) loads with normal daily activity between uniplane and biplane osteotomies is unclear. The purpose of this study was to reveal the differences in PFJ biomechanics between uniplane and biplane OWHTO using finite element analysis (FEA).
View Article and Find Full Text PDFA pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies.
Sci Rep
January 2025
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
This paper describes the design and initial proof-of-concept of a single pre-clinical transcranial focused ultrasound (FUS) system capable of performing histotripsy (mechanical ablation), hyperthermia, blood-brain barrier opening (BBBO), sonodynamic therapy, or neuromodulation in a murine brain. We have termed it the All-in-One FUS system for murine brain studies, which is the first FUS system of its kind. The 1.
View Article and Find Full Text PDFWater-Resistant Poly(vinyl alcohol)/ZnO Nanopillar Composite Films for Antibacterial Packaging.
ACS Omega
December 2024
Guangxi Colleges and Universities Key Laboratory of New Technology and Application in Resource Chemical Engineering, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
To solve the problems that poly(vinyl alcohol) (PVA) easily breeds bacteria and swells in a humid environment, PVA and ZnO nanopillar (ZnO NP) components were composed to generate PVA/ZnO NP composite films via a simple combination process of blending and heat treatment in this study. Here, ZnO NPs endowed composite films with good antibacterial properties, and the etherification and dehydration of hydroxyl groups between PVA molecular chains induced by heat treatment resulted in the composite films having excellent water-swelling resistance. Most importantly, PVA/ZnO NP composite films revealed excellent tensile strength in both humid (52.
View Article and Find Full Text PDFEngagement in moderate-intensity physical activity supports overnight memory retention in older adults.
Sci Rep
December 2024
Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Preserving the ability to vividly recall emotionally rich experiences contributes to quality of life in older adulthood. While prior works suggest that moderate-intensity physical activity (MPA) may bolster memory, it is unclear whether this extends to emotionally salient memories consolidated during sleep. In the current study, older adults (mean age = 72.
View Article and Find Full Text PDFCharacterization of yellowfin tuna (Thunnus albacares) skin gelatin extracted by bromelain hydrolysis and ultrasound pre-treatment.
J Food Sci
December 2024
Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah mada University, Yogyakarta, Indonesia.
Article Synopsis
- The study explores using hydrolysis of yellowfin tuna skin waste as an eco-friendly method to produce gelatin, and highlights ultrasound pre-treatment as a way to enhance extraction efficiency.
- Factors like ultrasound amplitude, pre-treatment duration, enzyme concentration, and hydrolysis time were tested to determine optimal conditions for maximizing yield and quality of gelatin, which resulted in specific optimal parameters.
- The final gelatin showed promising properties such as high viscosity, gel strength, emulsifying abilities, antioxidant activity, and good digestibility, marking a step towards sustainable gelatin production from fish waste.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!