AI Article Synopsis
- The study explored how age influences cognitive decline in Alzheimer's disease patients aged 64 and older, focusing on three age groups: young-onset (under 65), middle-onset (65-74), and late-onset (75 and over).
- The research analyzed data from 305 participants, measuring cognitive decline using the Mini-Mental State Examination (MMSE) and employing multilevel models for analysis.
- Findings showed that younger patients (YOAD) experienced the fastest decline at 2.8 points per year, while older patients (LOAD) had a slower decline at 1.4 points per year, indicating a generally better prognosis for older patients.
Article Abstract
Background: There is only limited information available about the effect of age on course of cognitive decline in patients with onset of Alzheimer's disease (AD) over the age of 64 years.
Objective: We compared the rate of, and factors affecting, cognitive decline in patients with AD aged < 65 years (young-onset AD), 65-74 years (middle-onset AD), and ≥75 years (late-onset AD).
Method: The study used longitudinal data from the Essex Memory Clinic which included a total of 305 participants; 56 had YOAD, 73 had MOAD, and 176 had LOAD. The rate of cognitive decline was measured using scores from the Mini-Mental State Examination (MMSE), and the data were examined using multilevel models analysis.
Results: There was evidence of a difference in cognitive decline across the age groups with the YOAD group declining 2.8 MMSE points per year, those with MOAD declined 2.0 MMSE points per year, and the LOAD group declined 1.4 MMSE points per year.
Conclusions: Patients with LOAD have a better prognosis than YOAD and MOAD. However, even between the MOAD and LOAD groups, age is a significant predictor of cognitive decline, with older patients having a more benign course.
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| http://dx.doi.org/10.3233/JAD-181047 | DOI Listing |
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