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Case report: Resolution of VIPoma-related symptoms with peptide receptor radionuclide therapy.
Front Oncol
January 2025
Department of Nuclear Medicine, Mount Sinai Hospital at Icahn School of Medicine, New York, NY, United States.
Peptide receptor radionuclide therapy (PRRT) is used for the management of neuroendocrine tumors (NETs) not responsive to somatostatin analogs. In this case series, we report two patients with pancreatic vasoactive intestinal peptide (VIP)-secreting NETs (VIPomas) not responsive to any other therapies who achieved symptomatic control and a significant decrease in serum VIP levels with PRRT during their hospital stay. Two patients with VIPomas were admitted to the hospital with multiple prior hospital admissions after going through multiple lines of therapy.
View Article and Find Full Text PDFRegulation of intestinal tissue‑resident memory T cells: a potential target for inflammatory bowel disease.
Cell Commun Signal
December 2024
Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Tissue-resident memory T (TRM) cells are populations which settle down in non-lymphoid tissues instead of returning to secondary lymph organs after the antigen presentation. These cells can provide rapid on-site immune protection as well as long-term tissue damage. It is reported that TRM cells from small intestine and colon exhibited distinctive patterns of cytokine and granzyme expression along with substantial transcriptional and functional heterogeneity.
View Article and Find Full Text PDFAlbi score predicts overall survival (OS) in patients with hepatocellular carcinoma (HCC) treated with selective internal radiation therapy (SIRT).
Radiol Med
December 2024
Interventional Radiology Unit, Department of Diagnostic Imaging and Interventional Radiology, A.O.U. Città Della Salute e della Scienza Di Torino, Turin, Italy.
Purpose: We aimed to evaluate the prognostic impact of baseline clinical features and treatment procedure, including liver function measured with albumin-bilirubin (ALBI) formula and dosing methods in HCC patients treated with SIRT.
Material And Methods: The study includes 82 consecutive patients with liver-dominant HCC treated with SIRT (Y glass microspheres, TheraSphereTM) between October 2014 and September 2023. Twenty-five patients were treated with standard dosimetry, while for remaining patients, multi-compartment dosimetry was performed using Simplicit90YTM software.
Nickel-induced multimetal uptake in two microalgal species (Chlorella sorokiniana and Chlamydomonas reinhardtii) and its effect on growth and lipid unsaturation.
J Trace Elem Med Biol
December 2024
Department of Chemistry, University of Crete, Voutes Campus, Heraklion 70013, Greece; Environmental Chemical Processes Laboratory, University of Crete, Voutes Campus, Heraklion 70013, Greece. Electronic address:
As the concern for Ni contamination in the aquatic environment escalates, efforts for microalgal use in environmental monitoring and bioremediation are increasing. This study aims to evaluate the potential of Chlorella sorokiniana and Chlamydomonas reinhardtii for Ni bioremediation by investigating their physiological stress responses in Ni-contaminated environments. The analysis focuses on how Ni(II) uptake affects cell growth, nutrient metal homeostasis, and lipid unsaturation levels, as these parameters are critical indicators of metabolic stability and resilience essential for effective bioremediation.
View Article and Find Full Text PDFEven moderate liver fat accumulation below conventional fatty liver cutoffs is linked to multiple metabolomic alterations and gestational dysglycemia in Asian women of reproductive age.
BMC Med
November 2024
Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore, 117609, Singapore.
Article Synopsis
- * In a sample of 382 Asian women planning to conceive, the research identifies a new liver fat cutoff of 2.07% for diagnosing MetS, with trends indicating worsened MetS traits and plasma metabolomic changes as liver fat increases.
- * Results show that preconception liver fat levels significantly correlate with the risk of gestational diabetes, with moderate liver fat (2.07% to 5.56%) doubling and high liver fat (≥5.56%) increasing the risk seven
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