AI Article Synopsis
- Hyaluronan-based microgels with an artificial extracellular matrix were developed using a microfluidic technique and incorporated into a HA/collagen hydrogel, enhancing the retention of noncrosslinked sHA3.
- The modified gels showed an increased binding capacity for transforming growth factor-β1 (TGF-β1) compared to standard HA/collagen hydrogels.
- These advancements suggest potential for creating new biomaterials that can control the release of sHA3 and interact with growth factors, which could aid in skin repair by normalizing TGF-β1 levels.
Article Abstract
Hyaluronan (HA)-based microgels generated in a microfluidic approach, containing an artificial extracellular matrix composed of collagen and high-sulfated hyaluronan (sHA3), were incorporated into a HA/collagen-based hydrogel matrix. This significantly enhanced the retention of noncrosslinked sHA3 within the gels enabling controlled sHA3 presentation. Gels containing sHA3 bound higher amounts of transforming growth factor-β1 (TGF-β1) compared to pure HA/collagen hydrogels. Moreover, the presence of sHA3-containing microgels improved the TGF-β1 retention within the hydrogels. These findings are promising for developing innovative biomaterials with adjustable sHA3 release and growth factor interaction profiles to foster skin repair, e.g., by rebalancing dysregulated TGF-β1 levels.
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| http://dx.doi.org/10.1007/s10856-019-6267-1 | DOI Listing |
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