Head injury in childhood is the most common cause of death or permanent disability from injury. However, insufficient understanding exists of the response of a child's head to injurious loading scenarios to establish cause and effect relationships to assist forensic and safetly investigations. Largely as a result of a lack of availability of paediatric clinical and Post-Mortem-Human-Surrogate (PMHS) experimental data, a new approach to infant head injury experimentation has been developed. A coupled-methodology, combining a physical infant head surrogate, producing "real world" global, regional and localised impact response data and a computational Finite-Element (FE-head) model was created and validated against available PMHS and physical model global impact response data. Experimental impact simulations were performed to investigate regional and localised injury vulnerability. Different regions of the head produced accelerations significantly greater than those calculated using the currently available method of measuring the global, whole head response. The majority of material strain was produced within the relatively elastic suture and fontanelle regions, rather than the skull bones. A subsequent parametric analysis was conducted to provide a correlation between fall height and areas of maximum-stress-response and fracture-risk-probability. The FE-head was further applied to investigating fracture risk, simulating injurious PMHS impacts and a good qualitative match was observed. The FE-head shows significant potential for the study of infant head injury and is anticipated to be a motivating tool for the improvement of head injury understanding across a range of potentially injurious head loading scenarios.
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http://dx.doi.org/10.1016/j.forsciint.2019.04.034 | DOI Listing |
BMJ Open
December 2024
Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent University, Gent, Belgium.
Introduction: A vestibular deficit can have a substantial impact on the overall development of children. Therefore, it is of utmost importance that vestibular-impaired problems are treated early and effectively through Vestibular Rehabilitation Therapy (VRT). Although VRT is sufficiently proven and standardised in adults, there remains a lack of research examining its efficacy in children.
View Article and Find Full Text PDFSyst Rev
January 2025
Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Background: Impaired intrauterine growth, a significant global health problem, contributes to a higher burden of infant morbidity and mortality, mainly in resource-poor settings. Maternal anemia and undernutrition, two important causes of impaired intrauterine growth, are prioritized by global nutrition targets of 2030. We synthesized the evidence on the role of preconception nutrition supplements in reducing maternal anemia and improving intrauterine growth.
View Article and Find Full Text PDFCardiovasc Diabetol
January 2025
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010, Málaga, Spain.
Background: The prevalence of obesity and type 2 diabetes mellitus (T2DM) is rising globally, particularly among children exposed to adverse intrauterine environments, such as those associated with gestational diabetes mellitus (GDM). Epigenetic modifications, specifically DNA methylation, have emerged as mechanisms by which early environmental exposures can predispose offspring to metabolic diseases. This study aimed to investigate DNA methylation differences in children born to mothers with GDM compared to non-GDM mothers, using saliva samples, and to assess the association of these epigenetic patterns with early growth measurements.
View Article and Find Full Text PDFTurk Arch Pediatr
January 2025
Department of Biostatistics, Lokman Hekim University Faculty of Medicine, Ankara, Türkiye.
Objective: Growth curves are important tools for assessing the growth and development of children in the target population by age. Measuring head circumference (HC) in infants is an important tool in monitoring infant health and brain development. The aims of this study are to construct current 0-2-year-old HC growth curves and percentiles and compare the methods used in the construction of growth curves for HC measurements by gender.
View Article and Find Full Text PDFDev Neurorehabil
January 2025
Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Background: Positional plagiocephaly or brachycephaly (PPB), linked to developmental delays and asymmetrical features, often prompts parental concern and medical consultation.
Objective: This qualitative study explores factors influencing parental adherence to PPB prevention strategies.
Methods: Fifteen parents of newborns participated in semi-structured interviews.
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