The selective cleavage of thermodynamically stable C(sp )-C(sp ) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for C -C bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general synthon for amides and provides valuable possibilities for their scalable functionalization in, for example, natural products and bioactive molecules.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771714 | PMC |
| http://dx.doi.org/10.1002/anie.201903019 | DOI Listing |
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