A zinc-/quinine-mediated enantioselective Aldol-type reaction of trifluorodiazoethane (CFCHN) with various aldehydes is described. This study demonstrated the feasibility of utilizing CFCHN as an effective hard nucleophile in catalytic asymmetric transformations. Furthermore, the synthetic utility of this protocol is exemplified by the construction of a diverse set of chiral β-trifluoromethylated alcohols, including a valuable HDAC inhibitor precursor.
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| http://dx.doi.org/10.1021/acs.orglett.9b01468 | DOI Listing |
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