AI Article Synopsis
- Photosensitisers can be activated by light to produce reactive oxygen species (ROS), which may help treat diseases by destroying unhealthy tissues and tumors.
- A new class of photosensitiser has been developed with a small, drug-like structure that is effective when exposed to UV-A or near-infrared light, leading to strong cell-killing effects through ROS generation.
- Experiments showed that this process effectively produced ROS and targeted cell destruction in specific parts of a zebrafish embryo.
Article Abstract
Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by , has been designed possessing a modular, low molecular weight and 'drug-like' structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of cellular assays confirmed ROS formation and cytotoxic activity was exemplified irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495688 | PMC |
| http://dx.doi.org/10.1039/c9sc00199a | DOI Listing |
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