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Quercetin can improve anesthesia induced neuroinflammation and cognitive dysfunction by regulating miR-138-5p/ LCN2.
BMC Anesthesiol
January 2025
Department of Neurosurgery, Xijing Hospital, No. 127, Changle West Road, Xi'an, 710032, China.
Background: Anesthesia can lead to functional cognitive impairment, which can seriously affect postoperative recovery. To investigate the effect and mechanism of quercetin (Que) in anesthetized rats, the study provided a new therapeutic idea for the prevention of cognitive dysfunction caused by anesthesia.
Methods: Cognitively impaired rats were constructed using Isoflurane (ISO) anesthesia and treated with Que.
Friends to remember: innate immune memory regulation by the microbiota.
Trends Microbiol
January 2025
Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA, Derio, Spain; Ikerbasque, Basque Foundation for Science, Bilbao, Spain. Electronic address:
Innate immune memory (IIM) is the process by which, upon a primary challenge, innate immune cells alter their epigenetic, transcriptional, and immunometabolic profiles, resulting in modified secondary responses. Unlike infections or other immune-system-related diseases, the role of IIM in nonpathogenic contexts is less understood. An increasing body of research has shown that normal microbiota members or their metabolic byproducts induce alternative memory phenotypes, suggesting that memory cells contribute to homeostasis in mucosal areas.
View Article and Find Full Text PDFAdults are capable of either differentiating or integrating similar events in memory based on which representations are optimal for a given situation. Yet how children represent related memories remains unknown. Here, children (7-10 years old) and adults formed memories for separate yet overlapping events.
View Article and Find Full Text PDFThe influence of acute alcohol intoxication and hair visibility on delayed face recall.
Memory
January 2025
Department of Psychology, University of Portsmouth, Portsmouth, UK.
Many witnesses are intoxicated at crime scenes, yet little is known of their ability to accurately describe perpetrators to police. We therefore explored the impact of alcohol on delayed verbal face recall across two experiments. Participants were administered an alcoholic or non-alcoholic beverage prior to viewing either one or two unfamiliar female faces, which they described from memory the following day while in a sober state.
View Article and Find Full Text PDFActivation and memory of the heatshock response is mediated by Prion-like domains of sensory HSFs in Arabidopsis.
Mol Plant
January 2025
Leibniz Institut für Gemüse und Zierpflanzenbau (IGZ) e.V., Großbeeren, Germany; Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany. Electronic address:
Plants are able to sense and remember heat stress. An initial priming heat stress enables plants to acclimate so that they are able to survive a subsequent higher temperature. The heatshock transcription factors (HSFs) play a crucial role in this process, but the mechanisms by which plants sense heat stress are not well understood.
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