AI Article Synopsis
- High-resolution metabolomics profiling of maternal serum samples helps to understand how poly and perfluoroalkyl substances (PFASs) affect fetal health by altering their metabolic environment.
- Metabolome-Wide Association Studies (MWAS) revealed distinct metabolic profiles related to PFAS compounds, specifically highlighting differences between the precursor EtFOSAA and the end product PFOS.
- Key findings include opposing associations of urea cycle metabolites with these substances and unique links between PFOS and fatty acid metabolism, suggesting how PFAS exposure might contribute to health risks during pregnancy.
Article Abstract
High-resolution metabolomics (HRM) profiling of metabolic fingerprints can improve understanding of how poly and perfluoroalkyl substances (PFASs) induce metabolic alterations of in utero environment and impact fetal health. HRM profiling and quantification of PFASs were performed for 397 maternal perinatal serum samples collected from 1959-1967 in the Child Health and Development Studies (CHDS). We used Metabolome-Wide Association Studies (MWAS) and pathway enrichment analysis for metabolic associations with PFOS, its precursor EtFOSAA, and EtFOSAA-to-PFOS ratio. Distinct metabolic profiles were found with EtFOSAA and PFOS. Urea cycle metabolites such as arginine, lysine and creatine had opposite associations with EtFOSAA (negative) and PFOS (positive); whereas, carnitine shuttle metabolites were found to be exclusively and positively associated with PFOS indicating perturbation in fatty acid metabolism. These differential metabolic associations for precursor and end-product represent an important first step in identifying how PFASs alter the in utero environment and potentially leads to disease risk.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117788 | PMC |
| http://dx.doi.org/10.1016/j.reprotox.2019.05.058 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fluorine-rich poly(arylene amine) membranes for the separation of liquid aliphatic compounds.
Science
January 2025
State Key Laboratory of Coordination Chemistry, MOE Key Laboratory of High-Performance Polymer Materials & Technology, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
We explored the potential for membrane materials to reduce energy and carbon requirements for the separation of aliphatic hydrocarbon feedstocks and products. We developed a series of fluorine-rich poly(arylene amine) polymer membranes that feature rigid polymer backbones with segregated perfluoroalkyl side chains. This combination imbues the polymers with resistance to dilation induced by hydrocarbon immersion without the loss of solution-based membrane fabrication techniques.
View Article and Find Full Text PDFPhotodegradation of steroid hormone micropollutants with palladium-porphyrin coated porous PTFE of varied morphological and optical properties.
Water Res
December 2024
Institute for Advanced Membrane Technology (IAMT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany. Electronic address:
In flow-through reactors, the photodegradation rate can be improved by enhancing contact and increasing the photocatalyst loading. Both can be attained with a higher surface-to-volume ratio. While previous studies focused on thin membranes (30 - 130 µm) with small pore sizes of 20 - 650 nm, this work employed poly(tetrafluoroethylene) (PTFE) supports, of which pore sizes are in the order of 10 µm, while the porosities and thicknesses are variable (22.
View Article and Find Full Text PDFPer- and Polyfluoroalkyl Substances in Semen Associated with Repeated Measures of Semen Quality in Healthy Adult Men.
Environ Sci Technol
January 2025
College of Environment and Climate, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China.
Although epidemiological studies have explored the association between poly- and perfluoroalkyl substances (PFAS) concentrations and semen quality, existing findings are often inconsistent. Our work aimed to explore the association of PFAS in plasma and semen with repeated measures of semen quality parameters in healthy adults. Plasma was collected at the initial recruitment and semen was collected at least once within five predetermined intervals during an approximately 3-month period.
View Article and Find Full Text PDFBicontinuous Block Copolymer Microparticles through Hydrogen-Bonding-Mediated Dual Phase Separation between Polymer Segments and Fluorinated Additives.
ACS Nano
December 2024
Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education (HUST), Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China.
Bicontinuous microparticles have advanced transport, mechanical, and electrochemical properties and show promising applications in energy storage, catalysis, and other fields. However, it remains a great challenge to fabricate bicontinuous microparticles of block copolymers (BCPs) by controlling the microphase separation due to the extremely narrow region of a bicontinuous structure in the phase diagram. Here, we demonstrate a strategy to balance the phase separation of BCPs and fluorinated additives at different length scales in emulsion droplets, providing a large window to access bicontinuous microparticles.
View Article and Find Full Text PDFExposure to Poly- and Perfluoroalkyl Substances During Pregnancy and Asthma in Childhood: A Systematic Review.
Cureus
November 2024
Department of Midwifery, University of West Attica, Athens, GRC.
Asthma is a chronic respiratory disease that has been increasing in prevalence among children globally. While genetic factors contribute to asthma risk, there are growing concerns about environmental exposures, such as poly- and perfluoroalkyl substances (PFAS), which may disrupt respiratory and immune development in the prenatal period. This systematic review aimed to assess the association between prenatal PFAS exposure and the development of asthma in childhood, integrating findings from epidemiological studies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!