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Apelin-13 attenuates motor impairments and prevents the changes in synaptic plasticity-related molecules in the striatum of Parkinsonism rats. | LitMetric

Apelin-13 attenuates motor impairments and prevents the changes in synaptic plasticity-related molecules in the striatum of Parkinsonism rats.

Peptides

Laboratory of Molecular Neuroscience, Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences. Kerman, Iran; Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman. Kerman, Iran. Electronic address:

Published: July 2019

AI Article Synopsis

  • The study investigates the effects of apelin-13 on motor control and synaptic proteins in a rat model of Parkinson's disease, where dopamine levels are depleted.
  • After administering apelin-13 following a 6-OHDA injection, the research evaluated motor skills and changes in synaptic proteins crucial for motor function.
  • Results showed that apelin-13 significantly improved motor skills and protected striatal synaptic components, suggesting its potential benefits for treating neurodegenerative disorders.

Article Abstract

The striatum plays a critical role in motor control and also learning and memory of motor skills. It has been reported that striatal synaptic components are significantly decreased in dopaminergic-denervated striatum. In this study the effects of apelin-13 were investigated on motor disorders and striatal synaptosomal expression of PSD-95, neurexin1, neuroligin, metabotropic glutamate receptor (mGlu R1) and dopaminergic receptors (DR1 and DR2) in rat parkinsonism experimental model. 6-hydroxydopamine (6-OHDA) was injected into the substantia nigra. Apelin-13 (1, 2 and 3 μg/rat) was administered into the substantia nigra one week after the 6-OHDA injection. Accelerating rotarod, beam-balance, beam-walking and bar tests were performed one month after the apelin injection. Immunohistochemistry staining of dopaminergic neurons was performed. The levels of synaptic proteins were determined by immunoblotting. 6-OHDA-treated animals showed a significant impairment in motor-skill tasks and a dramatically change in the expression levels of mentioned proteins. Apelin-13 (3 μg/rat) significantly attenuates the motor impairments and prevents the changes in striatal synaptic elements in 6-OHDA-treated animals. In addition, it could rescue the dopaminergic neurons of the substantia nigra. The data will potentially extend the possible benefic aspect of apelin in neurodegenerative disorders.

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Source
http://dx.doi.org/10.1016/j.peptides.2019.05.003DOI Listing

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