A catalytic carbonylative ring-opening and functionalization reaction of poorly activated cyclopropanes has been developed. The key achievement of this work is the accomplishment of an unprecedented effective intermolecular trapping of the rhodacyclopentanone intermediate, which is derived from rhodium-mediated carbonylative insertion of poorly activated cyclopropanes, by an external reactant. The success of this development hinges upon the use of a dual directing strategy.
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| http://dx.doi.org/10.1021/acs.orglett.9b01420 | DOI Listing |
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