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Understanding Trigger Linkage Dynamics in Energetic Materials Using Mixed Picramide Nitrate Ester Explosives.
J Phys Chem Lett
January 2025
High Explosives Science and Technology, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
The ability to predict the handling sensitivity of new organic energetic materials has been a longstanding goal. We report the synthesis and characterization of six new nitropicramide energetic materials with mixed functional groups that mimic known explosives such as nitroglycerin, erythritol tetranitrate (ETN), and pentaerythritol tetranitrate (PETN). The molecules have been studied theoretically using quantum molecular dynamics (QMD) simulations and density functional theory (DFT) calculations to identify the weakest bond in the reactants - the trigger-linkages - which control handling sensitivity, and to quantify their specific enthalpies of explosion.
View Article and Find Full Text PDFThe use of a methylene blue and glyceryl trinitrate-based cream for the treatment of chronic anal fissures: a phase II randomized pilot trial from a referral coloproctological unit.
Tech Coloproctol
January 2025
Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J), Section of Surgery, General Surgery Unit - Hospital University of Bari, Piazza Giulio Cesare 11, 70124, Bari, SE, Italy.
Background: Chronic anal fissures (CAFs) are the second most common anorectal disease. Non-surgical treatment includes several options with controversial efficacy. The aim of this study was to evaluate the efficacy and safety of a new ointment based on methylene blue in addition to glyceryl trinitrate.
View Article and Find Full Text PDFFeasibility and Clinical Efficacy of Focal Pulsed Field Ablation in Patients With Non-Pulmonary Vein Triggered Atrial Arrhythmia From the Superior Caval Vein.
J Cardiovasc Electrophysiol
December 2024
Arrhythmia Section, Division of Cardiology, Heart Center, Zentralklinik Bad Berka, Bad Berka, Germany.
Introduction: In patients with atrial arrhythmias originating from the superior vena cava (SVC), the use of radiofrequency energy to isolate the SVC is associated with a significant risk of injury both to the phrenic nerve and the sinus node. Pulsed field ablation (PFA) may overcome the disadvantages of thermal energy and improve both ablation efficacy and safety.
Objective: We report the feasibility, safety, and clinical efficacy of focal monopolar PFA in patients with the origin of their atrial arrhythmia in the SVC.
The neurotrophic factor artemin and its receptor GFRα3 mediate migraine-like pain via the ion channel TRPM8.
Cephalalgia
November 2024
Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Article Synopsis
- Genetic Basis of Migraine
- : Migraine is largely polygenic, with many genetic variants identified through genome-wide association studies. Key mutations are linked to the TRPM8 channel, which senses cold but may have different activation mechanisms related to migraine.
- Role of Artemin and GFRα3
- : The study explores how the neurotrophic factor artemin and its receptor GFRα3 influence migraine-related pain through their effects on TRPM8, potentially affecting cold sensitivity and pain responses in migraine models.
- Preclinical Findings
- : Experiments on mice show that GFRα3 is crucial for mechanical sensitivity in migraine, as blocking artemin reduces migraine-like symptoms, highlighting its significance in
Word of caution: clinically apparent coronary spasm following pulsed field cavotricuspid isthmus ablation despite nitroglycerin prophylaxis - a case report.
Eur Heart J Case Rep
November 2024
Department of Cardiology and Intensive Care Medicine, Asklepios Hospital St. Georg, Lohmühlenstr. 5, Hamburg 20099, Germany.
Background: Pulsed field ablation (PFA) is a novel ablation technology. A rare side-effect is the occurrence of mostly subclinical coronary spasms when PF energy is applied in proximity to coronary arteries. However, it has been described that prior application of nitroglycerin attenuates these effects.
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