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| http://dx.doi.org/10.1007/s12551-019-00540-3 | DOI Listing |
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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Background: Cognitive decline is often influenced by Alzheimer's disease (AD) pathology (e.g., beta-amyloid burden) and other pathology (e.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: The newly proposed criteria by the AA working group incorporates both biological and clinical stages to characterize the progression of AD. In this study, we aim to evaluate the agreement between these two complementary systems.
Methods: Using 188 participants from McGill TRIAD and 139 from the HEAD cohorts, we categorized participants into biological (0-4) and clinical (0-4) stages using amyloid PET, tau PET(MK-6240), and clinical measures as described by the working group.
Assessment of lung function in partially edentulous patients using spirometry: A cross-sectional study.
J Indian Prosthodont Soc
January 2025
Department of Dental Materials, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.
Aim: This study aimed to evaluate the effect of partially edentulous ()PED condition on lung function through spirometry tests and comparison of airflow rates between dentulous and PED subjects.
Settings And Design: The study design was a cross-sectional study conducted in the department of prosthodontics.
Materials And Methods: Twenty-eight dentulous and 28 PED patients with an age range of 25-50 years were included in the study.
h-CMD: An efficient hybrid fast centroid and quasi-centroid molecular dynamics method for the simulation of vibrational spectra.
J Chem Phys
January 2025
Division of Energy, Matter and Systems, School of Science and Engineering, University of Missouri-Kansas City, Kansas City, Missouri 64110, USA.
Developing efficient path integral (PI) methods for atomistic simulations of vibrational spectra in heterogeneous condensed phases and interfaces has long been a challenging task. Here, we present the h-CMD method, short for hybrid centroid molecular dynamics, which combines the recently introduced fast quasi-CMD (f-QCMD) method with fast CMD (f-CMD). In this scheme, molecules that are believed to suffer more seriously from the curvature problem of CMD, e.
View Article and Find Full Text PDFDiffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Demonstrates That Sleep Disorders Exacerbate Glymphatic Circulatory Impairment and Cognitive Impairment in Patients with Alzheimer's Disease.
Nat Sci Sleep
December 2024
Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People's Republic of China.
Objective: Sleep disorders are common in Alzheimer's disease (AD) patients and can impair the glymphatic system, leading to cognitive decline. This study aimed to investigate whether AD patients with sleep disorders exhibit worse glymphatic function and more severe cognitive impairment compared to those without sleep disorders and to explore the underlying molecular imaging mechanisms.
Methods: This study included 40 AD patients with sleep disorders (ADSD), 39 cognitively matched AD patients without sleep disorders (ADNSD), and 25 healthy middle-aged and elderly controls (NC).
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