Organophosphorus pesticides (OPs) play a certain role in promoting the development of agriculture and forestry, but they may cause potential harm to aquatic life when entering rivers and polluting water sources. Previous researches have shown that OPs participate in the regulation mechanism of aquatic organisms. Here, our aim is to determine the underlying mechanisms of one OP (dimethoate) at the transcriptional level using the clam Meretrix meretrix. 4119 DEGs were obtained from high-throughput RNA sequencing data. Then, expression profiles of some genes were verified by qPCR, which showed a positive correlation with the RNA sequencing results. 14,481 simple sequence repeats were also identified and could be further used as molecular markers. In addition, some oxidative, immune, and stress-related genes were further discussed and could also be used as biomarkers to indicate the biological response of dimethoate. This study will help to better understand the clam's response mechanism to dimethoate stress.
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