AI Article Synopsis
- Circular RNAs (circRNAs) were once deemed "junk" but are now recognized as important genetic regulators with various functions, including acting as RNA-binding proteins and microRNA sponges.
- They are stable and conserved across different species and tissues, suggesting they could serve as promising molecular biomarkers for diseases, especially cancer.
- Recent studies highlight their significant roles in cardiovascular diseases, including heart failure and myocardial infarction, prompting further investigation into their diagnostic and prognostic potential.
Article Abstract
Circular RNAs (circRNAs) are genetic regulators that were earlier considered as "junk". In contrast to linear RNAs, they have covalently linked ends with no polyadenylated tails. CircRNAs can act as RNA-binding proteins, sequestering agents, transcriptional regulators, as well as microRNA sponges. In addition, it is reported that some selected circRNAs are transformed into functional proteins. These RNA molecules always circularize through covalent bonds, and their presence has been demonstrated across species. They are usually abundant and stable as well as evolutionarily conserved in tissues (liver, lung, stomach), saliva, exosomes, and blood. Therefore, they have been proposed as the "next big thing" in molecular biomarkers for several diseases, particularly in cancer. Recently, circRNAs have been investigated in cardiovascular diseases (CVD) and reported to play important roles in heart failure, coronary artery disease, and myocardial infarction. Here, we review the recent literature and discuss the impact and the diagnostic and prognostic values of circRNAs in CVD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511224 | PMC |
| http://dx.doi.org/10.7717/peerj.6831 | DOI Listing |
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