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Ochronotic Chondropathy: A Case Report.
Biomedicines
September 2023
Department of Orthopedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Article Synopsis
- Endogenous ochronosis, or alkaptonuria, causes notable discoloration of skin, eyes, and urine, often leading to joint degradation requiring surgeries.
- While some aspects of the disease have been studied, uncertainties remain about how this pigmentation occurs and why some tissues resist damage.
- This report details a case study of an 83-year-old woman with alkaptonuria, discussing the latest findings on the disease's cellular and mechanical effects on cartilage, and how its study may inform broader skeletal biology and treatments for related conditions like osteoarthritis.
Dermoscopic and in vivo reflectance confocal microscopic features of endogenous ochronosis.
Indian J Dermatol Venereol Leprol
August 2024
Department of Pathology, Medical Faculty, Ege University, Izmir, Turkey.
Endogenous Ochronosis: A Rare Entity.
Indian Dermatol Online J
June 2022
Department of Dermatology, Venereology and Leprology, Mahatma Gandhi Medical College, Navi Mumbai, Maharashtra, India.
Blue discoloration of the skin and cartilage, or ochronosis, is a rare physical examination finding. We present two cases of childhood onset ochronosis, one exogenous and one endogenous in etiology. The first was caused by minocycline use for severe acne, and the second was caused by congenital alkaptonuria.
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