AI Article Synopsis
- The Warburg effect, a key feature of cancer cells, involves a shift to aerobic glycolysis to support their growth and survival in various tumor environments.
- Researchers found that the Crassostrea gigas oyster can naturally exhibit this metabolic reprogramming, making it a valuable model for cancer research.
- The oyster's ability to adapt its metabolism to extreme environmental changes provides insights into how the Warburg effect may be regulated in a way that's not possible to study in vertebrate models.
Article Abstract
The Warburg effect is one of the hallmarks of cancer cells in humans. It is a true metabolic reprogramming to aerobic glycolysis, allowing cancer cells to meet their particular energy needs for growth, proliferation, and resistance to apoptosis, depending on the microenvironment they encounter within the tumor. We have recently discovered that the Crassostrea gigas oyster can naturally reprogram its metabolism to the Warburg effect. Thus, the oyster becomes a new invertebrate model useful for cancer research. Due to its lifestyle, the oyster C. gigas has special abilities to adapt its metabolism to the extreme changes in the environment in which it is located. The oyster C. gigas is therefore a model of interest to study how the environment can control the Warburg effect under conditions that could not be explored in vertebrate model species.
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| http://dx.doi.org/10.1051/medsci/2019079 | DOI Listing |
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