We report on a case of carcinoma cuniculatum (CC) of the maxillary gingival mucosa. A 60-year-old woman presented with an exophytic gingivo-palatal mass with slow growth and osteolytic evolution. A first performed biopsy was negative for malignancy. The diagnosis of CC was established on the surgical representative biopsy. CC is a rare low-grade variant of squamous cell carcinoma that is usually found in the foot or in oral cavity. The pathognomonic microscopic feature of CC is an endo- and/or exophytic lesion composed by a well differentiated squamous epithelium infiltrating into underlying stroma forming a complex pattern of keratin cores and keratin filled "rabbit warren" crypts. CC is a locally evolutive carcinoma with a usually good prognosis usually without lymph node or distant metastatic evolution.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.annpat.2019.03.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prognostic implications across histological subtypes of head and neck squamous cell carcinoma: An update.
J Stomatol Oral Maxillofac Surg
November 2024
Department of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address:
Article Synopsis
- * This review examines existing research on the prognostic implications of HNSCC’s histopathologic subtypes, noting a lack of studies focusing specifically on treatment outcomes for each subtype.
- * The review highlights that some subtypes, like verrucous and cuniculatum, have better prognoses compared to others like basaloid and spindle cell, and it emphasizes the need for more molecular research to develop targeted therapies and improve prognostic assessments.
Consider Carcinoma Cuniculatum in Recurrent Foot Ulcer: A Case Report and Literature Review.
Arch Plast Surg
November 2024
Department of Plastic Surgery, Hospital General Universitario Dr. Balmis, Alicante, Spain.
Carcinoma cuniculatum is a variant of squamous cell carcinoma, characterized by a slow growth with progressive crypt-like invasion of deep tissue. This tumor is frequently misdiagnosed as a benign skin lesion both clinically and histopathologically. The final diagnosis is often delayed as it requires a large sample biopsy.
View Article and Find Full Text PDFInvasive Cuniculatum Carcinoma of the Groin Mimicking Hidradenitis Suppurativa.
Am J Dermatopathol
January 2025
Department of Dermatology, University Hospital of Limoges, Limoges, France ; and.
Carcinoma Cuniculatum, a Rare Variant of Oral Squamous Cell Carcinoma: Presentation of Five Clinical Cases and Review of the Literature.
J Maxillofac Oral Surg
August 2024
Oral and Maxillofacial Surgery Department, University Hospital Ramon y Cajal, Madrid, Spain.
Background: Oral carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma. It exhibits a locally aggressive behaviour, and its histopathology poses a diagnostic challenge, as it can be mistaken for other conditions. We present five cases of oral CC treated at our institution and conduct a comprehensive review of the current literature.
View Article and Find Full Text PDFCarcinoma Cuniculatum Masquerading as Eumycetoma: An Unacquainted Entity Posing a Diagnostic Dilemma.
Turk Patoloji Derg
July 2024
Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, DELHI, INDIA.
Carcinoma cuniculatum (CC) is a rare and distinct clinicopathological variant of well-differentiated squamous cell carcinoma. It is a rare and slow-growing tumor with a peculiar infiltrative growth pattern resembling rabbit burrows (cuniculi). It usually occurs over the plantar aspect of the foot but can also occur at other sites like the oral cavity and genitals.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!