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Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness.
Front Immunol
December 2024
Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States.
Introduction: Despite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is a harbinger of poor long-term outcomes in sepsis survivors. Current dogma states that sepsis survivors are immunosuppressed, particularly in CCI.
View Article and Find Full Text PDFThe Horizon of Science.
Cureus
December 2024
Physical Medicine and Rehabilitation, Foundation Don Carlo Gnocchi, Milan, ITA.
The core of science is reasoning; assessment tools are an integral part of it. Mathematical/statistical calculation is a tool and is not equivalent to clinical reasoning. Statistics establish mathematical significance but do not always equally highlight clinical relevance.
View Article and Find Full Text PDFMeniscal tears affect patients of all ages, with varying presentations, influence on function, and treatment requirements. Classic dogma suggests that older patients should be treated nonoperatively or offered meniscectomy when conservative treatment fails. However, recent data suggest improved subjective outcomes and reduced rates of degenerative change after meniscal repair, even in patients older than 40 years.
View Article and Find Full Text PDFMultiple options exist for anterior cruciate ligament reconstruction autografts, including bone-patellar tendon-bone, quadriceps tendon, and hamstring tendon (HT). A variant among HT options is quadrupled semitendinosus autograft. In addition, smaller graft diameter (<8 mm) has been associated with failure of HT anterior cruciate ligament reconstruction.
View Article and Find Full Text PDFAnatomic anterior cruciate ligament (ACL) reconstruction is the gold standard treatment for ACL injury and has been shown to restore the 3-dimensional joint laxity. Recently, however, there is renewed interest in primary repair of the injured ACL in selected cases. Research shows that, in some cases, short- and midterm outcomes of ACL repair are favorable, albeit with greater failure rates than ACL reconstruction.
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