AI Article Synopsis
- Two studies investigated patients resistant to the drug methohexital during general anesthesia, finding that 9% of 513 patients required additional inhalation anesthetics for adequate sedation.
- The prospective study did not show any significant cardiovascular or blood gas changes that could explain the observed resistance in these patients.
- To keep patients adequately anesthetized, methohexital doses varied from 0.07 to 0.12 mg/kg/min, equating to 4.1 to 8.2 mg/min.
Article Abstract
Two studies were done to evaluate the patient who appears to be clinically resistant to incremental methohexital infusion for general anesthesia. A retrospective study revealed that 9% of the 513 patients developed resistance to methohexital maintenance and required a volatile inhalation anesthetic supplement. The cardiovascular and arterial blood gas analysis in a prospective study failed to disclose any gross changes that would explain the physiology associated with patients resistant to methohexital anesthesia. To maintain adequate anesthesia depth, doses of methohexital ranged from .07 to .12 mg/kg/min or 4.1 to 8.2 mg/min.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148564 | PMC |
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