Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695-705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363063 | PMC |
| http://dx.doi.org/10.1016/j.molmed.2019.04.011 | DOI Listing |
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