Three new biflavones, apigenin-(3',8″)-chrysin (), (2)-2,3-Dihydroametoflavone 5,4'-dimethyl ether (), and (2)-5″,7″-Dihydroxy-2″-phenoxychromonyl-(4'″,3')-naringenin (), together with seven known biflavones () were isolated from the 75% EtOH extract of . The structures of new compounds were established by application of spectroscopic methods, including 1D and 2D NMR, HRMS, and CD measurements. In addition, all new compounds were evaluated for their cytotoxic potential against three human cancer cell lines A549, MCF-7, and SMMC-7721 . Compound exhibited potent cytotoxic activity with IC values ranging from 6.35 to 10.18 μM.
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http://dx.doi.org/10.1080/14786419.2019.1611813 | DOI Listing |
Int J Mol Sci
December 2024
Department of Chemistry and Centre for Pharmacy, University of Bergen, N-5007 Bergen, Norway.
is a commercially important tree native to Japan. The tree belongs to the ancient genus and has found important uses as a medicinal plant, as well as a main source of timber in Japan. In recent years, there has been an increased interest in discovering extended uses of as a source of novel bioactive natural products with potential applications as lead compounds for active principles of future drugs.
View Article and Find Full Text PDFChem Biol Drug Des
June 2024
Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (B.H.U), Varanasi, India.
The leaves of Araucaria cunninghamii are known to be nonedible and toxic. Previous studies have identified biflavones in various Araucaria species. This study aimed to investigate the in vitro cytotoxicity of the isolated compounds from Araucaria cunninghamii after metabolomics and network pharmacological analysis.
View Article and Find Full Text PDFACS Omega
November 2023
Institute of Bioorganic Chemistry, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, Stetternicher Forst, Geb.15.8, 52426 Jülich, Germany.
In this work, we report the scalable and modular synthesis of a library of 55 monomeric and dimeric flavonoids including 14 8,8'-biflavones. The sterically demanding tetra--substituted axis of an acetophenone dimer key intermediate was constructed in a regioselective manner using Fe-mediated oxidative coupling. This step was systematically optimized and performed on up to multigram scale.
View Article and Find Full Text PDFPhytochemistry
July 2023
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Daegu, 41566, Republic of Korea. Electronic address:
During the screening of the cytotoxicity of rare Korean endemic plants, the extract of Thuja koraiensis Nakai displayed potent cytotoxicity against the adenocarcinomic human alveolar basal epithelial A549 cell line. Through a series of separations via column chromatography, three undescribed abietanes, an undescribed labdane along with a labdane, and a biflavonoid were purified from methylene chloride (CHCl) fraction possessing a potent cytotoxic effect. Extensive 1D and 2D NMR spectroscopic data analyses, in combination with quantum chemical calculations were conducted to establish the planar and absolute configurations of thujakoraienes A-C.
View Article and Find Full Text PDFFront Pharmacol
December 2022
The Clinical Medicine Research Center of the First Clinical Medical College, Gannan Medical University, Ganzhou, China.
Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system, which is highly invasive, metastatic, and insensitive to radiotherapy and chemotherapy. Chinese herbal medicine has always been an important source of anti-tumor drug development. Kunth is a traditional herb commonly used by the Miao nationality in southwest China.
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