Three new biflavones, apigenin-(3',8″)-chrysin (), (2)-2,3-Dihydroametoflavone 5,4'-dimethyl ether (), and (2)-5″,7″-Dihydroxy-2″-phenoxychromonyl-(4'″,3')-naringenin (), together with seven known biflavones () were isolated from the 75% EtOH extract of . The structures of new compounds were established by application of spectroscopic methods, including 1D and 2D NMR, HRMS, and CD measurements. In addition, all new compounds were evaluated for their cytotoxic potential against three human cancer cell lines A549, MCF-7, and SMMC-7721 . Compound exhibited potent cytotoxic activity with IC values ranging from 6.35 to 10.18 μM.

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http://dx.doi.org/10.1080/14786419.2019.1611813DOI Listing

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