The ion-irradiation damage effects in semiconductors were directly visualized by means of scanning electron microscopy at low beam acceleration voltages (low-kV SEM). The AlGaAs (p-type and n-type) epitaxial layers grown over GaAs substrates were irradiated with energetic He ions with fluencies ranging from 8e12 to 8e13 cm and studied in cross-sectional view after cleavage. Secondary electron images collected at low energy (0.5 - 1 keV) of primary electrons show strong contrast related to the local differences in the material resistivity resulting from the ion-induced damage. The main aim of the paper is to present, for the first time, the interpretation of the mechanism of SEM image contrast formation, which has been referred to as Damage-Induced Voltage Alteration (DIVA) contrast and is based on the charging effect in SEM. The unrivalled advantage of this imaging technique is the possibility of immediate two-dimensional visualization of damage effects without complex sample preparation.
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http://dx.doi.org/10.1016/j.ultramic.2019.04.013 | DOI Listing |
J Cell Physiol
April 2024
College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Selenium (Se), as one of the essential trace elements, plays an anti-inflammatory, antioxidation, and immune-enhancing effect in the body. In addition, Se can also improve nervous system damage induced by various factors. Earlier studies have described the important role of mitochondrial dynamic imbalance in lipopolysaccharide (LPS)-induced nerve injury.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2024
Department of Biochemistry, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Mitochondrial and lysosomal functions are intimately linked and are critical for cellular homeostasis, as evidenced by the fact that cellular senescence, aging, and multiple prominent diseases are associated with concomitant dysfunction of both organelles. However, it is not well understood how the two important organelles are regulated. Transcription factor EB (TFEB) is the master regulator of lysosomal function and is also implicated in regulating mitochondrial function; however, the mechanism underlying the maintenance of both organelles remains to be fully elucidated.
View Article and Find Full Text PDFFront Public Health
February 2023
Department of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, China.
Background: Excessive doses of electromagnetic radiation pose a negative impact on the central nervous system and lead to mental disorders. Molecular hydrogen can scavenge intracellular hydroxyl radicals, acting as an antioxidant, anti-apoptotic and anti-inflammatory agent. We seek to assess the capability of molecular hydrogen to ameliorate brain damage induced by electromagnetic radiation.
View Article and Find Full Text PDFInt J Mol Sci
December 2022
Department of Biological, Geological and Environmental Sciences, University of Catania, Via S. Sofia 64, 95123 Catania, Italy.
Damage induced by oxidative stress is a key driver of the selective motor neuron death in amyotrophic lateral sclerosis (ALS). Mitochondria are among the main producers of ROS, but they also suffer particularly from their harmful effects. Voltage-dependent anion-selective channels (VDACs) are the most represented proteins of the outer mitochondrial membrane where they form pores controlling the permeation of metabolites responsible for mitochondrial functions.
View Article and Find Full Text PDFNeurotoxicology
December 2022
Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom 73170, Thailand. Electronic address:
Cypermethrin (CYP), a synthetic pyrethroid of class II, is widely used as a pesticide worldwide. The primary target of cypermethrin is a voltage-gated sodium channel. The neurotoxicity of CYP has been extensively studied in terms of affecting neuronal development, increasing cellular oxidative stress, and apoptosis.
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