The precision and bias of Safety Performance Functions (SPFs) heavily rely on the data upon which they are estimated. When local (spatially and temporally representative) data are not sufficiently available, the estimated parameters in SPFs are likely to be biased and inefficient. Estimating SPFs using Bayesian inference may moderate the effects of local data insufficiency in that local data can be combined with prior information obtained from other parts of the world to incorporate additional evidence into the SPFs. In past applications of Bayesian models, non-informative priors have routinely been used because incorporating prior information in SPFs is not straightforward. The previous few attempts to employ informative priors in estimating SPFs are mostly based on local prior knowledge and assuming normally distributed priors. Moreover, the unobserved heterogeneity in local data has not been taken into account. As such, the effects of globally derived informative priors on the precision and bias of locally developed SPFs are essentially unknown. This study aims to examine the effects of globally informative priors and their distribution types on the precision and bias of SPFs developed for Australian crash data. To formulate and develop global informative priors, the means and variances of parameter estimates from previous research were critically reviewed. Informative priors were generated using three methods: 1) distribution fitting, 2) endogenous specification of dispersion parameters, and 3) hypothetically increasing the strength of priors obtained from distribution fitting. In so doing, the mean effects of crash contributing factors across the world are significantly different than those same effects in Australia. A total of 25 Bayesian Random Parameters Negative Binomial SPFs were estimated for different types of informative priors across five sample sizes. The means and standard deviations of posterior parameter estimates as well as SPFs goodness of fit were compared between the models across different sample sizes. Globally informative prior for the dispersion parameter substantially increases the precision of a local estimate, even when the variance of local data likelihood is small. In comparison with the conventional use of Normal distribution, Logistic, Weibull and Lognormal distributions yield more accurate parameter estimates for average annual daily traffic, segment length and number of lanes, particularly when sample size is relatively small.
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http://dx.doi.org/10.1016/j.aap.2019.04.023 | DOI Listing |
J Immunother Precis Oncol
February 2025
TopAlliance Biosciences Inc. Rockville, MD, USA.
Introduction: This was the first phase 1 study conducted in the United States. It consisted of dose-escalation (part A) and multiple indication-specific cohort expansion (part B), investigating the safety and preliminary efficacy of toripalimab (anti-programmed cell death-1 inhibitor) in patients with advanced malignancies.
Methods: Patients with advanced malignancies that progressed after treatment with at least one prior line of standard systemic therapy, including the patients with advanced/recurrent cholangiocarcinoma (CCA), received toripalimab 240 mg every 3 weeks in part B.
Front Child Adolesc Psychiatry
November 2024
Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Introduction: The COVID-19 pandemic had significant impacts on youth health and well-being. Youth with prior inequities, such as those exposed to child maltreatment, may have experienced greater psychosocial challenges and long-term difficulties than their peers, including sustained interpersonal relationships problems. Given the importance of healthy relationships during adolescence and early adulthood, the significant impact the pandemic had on youth, and the potential disproportionate challenges for youth with a child maltreatment history, the purpose of the present study was to better understand changes in relational conflict among youth with and without a child maltreatment history from the perspectives of youth themselves.
View Article and Find Full Text PDFCogn Neurodyn
December 2025
School of Mechatronical Engineering, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing, 100081 China.
Enhancing the accuracy of emotion recognition models through multimodal learning is a common approach. However, challenges such as insufficient modal feature learning in multimodal inference and scarcity of sample data continue to pose obstacles that need to be overcome. Therefore, we propose a novel adaptive lightweight multimodal efficient feature inference network (ALME-FIN).
View Article and Find Full Text PDFNarra J
December 2024
Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
The prevalence of willingness to undergo renal transplantation and its potentially associated factors have been documented in multiple prior studies across different regions, yet certain findings are conflicting. The aim of this study was to determine the global prevalence of willingness for renal transplantation and identify its associated factors through meta-analysis methods. Databases such as Scopus, PubMed, and Embase were utilized for the search strategy, covering the period from April to May 2024.
View Article and Find Full Text PDFNurse Res
January 2025
Griffith University, Nathan, Queensland, Australia.
Background: The vicarious trauma people who provide direct clinical care may experience is well documented. However, there is limited information about the vicarious trauma that researchers working with victim-survivors of domestic and family violence (DFV) or victimisation-related data may experience.
Aim: To describe and reflect on the vicarious trauma experienced by people researching DFV who have repeatedly been exposed to significant, traumatic data.
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