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Accurate colorectal cancer detection using a random hinge exponential distribution coupled attention network on pathological images.
Abdom Radiol (NY)
January 2025
Department of Computer Engineering, Vishwakarma Institute of Information Technology, Pune, India.
Colorectal cancer (CRC) is one of the most common and deadly forms of cancer worldwide, necessitating accurate and early detection to improve treatment outcomes. Traditional diagnostic methods often rely on manual examination of pathological images, which can be time-consuming and prone to human error. This study presents an advanced approach for colorectal cancer detection using a Random Hinge Exponential Distribution coupled Attention Network (RHED-CANet) on pathological images.
View Article and Find Full Text PDFImmunoinformatics: A Veritable Toolbox for Livestock Omics and Veterinomics.
OMICS
January 2025
Animal Biochemistry Division, ICAR - National Dairy Research Institute, Karnal, India.
Immunoinformatics, an integrative field consisting of bioinformatics and immunology, has showcased its potential in addressing zoonotic diseases, as evidenced during the Coronavirus disease 2019 (COVID-19) pandemic. However, its application in livestock health remains largely untapped. This opinion commentary explores how immunoinformatics, combined with advancements in genomics, multi-omics integration, and genome editing technologies, can revolutionize livestock management by enhancing disease resistance, vaccine development, and productivity.
View Article and Find Full Text PDFScreened Ni single-cluster catalyst supported on graphidyne for high-performance electrocatalytic NO reduction to NH: A computational study.
J Colloid Interface Sci
January 2025
Key Laboratory of Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, China. Electronic address:
Electrocatalytic NO reduction (NORR) to NH represents a promising approach for converting hazardous NO waste gases into high-value NH products under ambient conditions. However, exploring stable, low-cost, and highly efficient catalysts to enhance the NO-to-NH conversion process remains a significant challenge. Herein, through systematic computational studies based on density functional theory (DFT), we rationally designed transition metal triatomic cluster supported on graphdiyne (TM/GDY) as potential single-cluster catalysts for high-performance NORR.
View Article and Find Full Text PDFLiver parasites: A global endemic and journey from infestation to intervention.
World J Gastroenterol
January 2025
Department of Medicine, Section of Gastroenterology, Aga Khan University Hospital, Karachi 75500, Sindh, Pakistan.
Parasites have coexisted with humans throughout history, forming either symbiotic relationships or causing significant morbidity and mortality. The liver is particularly vulnerable to parasitic infections, which can reside in, pass through, or be transported to the liver, leading to severe damage. This editorial explores various parasites that infect the liver, their clinical implications, and diagnostic considerations, as discussed in the article "Parasites of the liver: A global problem?".
View Article and Find Full Text PDFActivators of the 26S proteasome when protein degradation increases.
Exp Mol Med
January 2025
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA.
In response to extra- and intracellular stimuli that constantly challenge and disturb the proteome, cells rapidly change their proteolytic capacity to maintain proteostasis. Failure of such efforts often becomes a major cause of diseases or is associated with exacerbation. Increase in protein breakdown occurs at multiple steps in the ubiquitin-proteasome system, and the regulation of ubiquitination has been extensively studied.
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