AI Article Synopsis
- Aortic calcification is linked to arterial stiffening and increased risk of heart-related issues, and F-sodium fluoride (F-NaF) uptake can indicate active calcification areas in the aorta.
- A study involving 21 postmenopausal women measured F-NaF uptake and aortic calcium volume over approximately 3.8 years, showing an increase in calcium volume but no correlation with the initial F-NaF uptake levels.
- The findings suggest that F-NaF uptake in the aorta does not effectively predict the progression of aortic calcification in postmenopausal women over the four-year period studied.
Article Abstract
Introduction: Aortic calcification as detected by computed tomography is associated with arterial stiffening and is an important predictor of cardiovascular morbidity and mortality. Uptake of F-sodium fluoride (F-NaF) in the aortic wall reflects metabolically active areas of calcification. The aim of this study was to determine if F-NaF uptake in the aorta is associated with calcification and progression of calcification as detected by computed tomography.
Methods: Twenty-one postmenopausal women (mean age 62 ± 6 years) underwent assessment of aortic F-NaF uptake using positron emission tomography/computer tomography at baseline and a repeat computed tomography scan after a mean follow-up of 3.8 ± 1.3 years. Tracer uptake was quantified by calculating the target-to-background (TBR) ratios at baseline and follow-up. Calcification was assessed at baseline and follow-up using computed tomography.
Results: Over the follow-up period, aortic calcium volume increased from 0.46 ± 0.62 to 0.71 ± 0.93 cm ( < 0.05). However, the change in calcium volume did not correlate with baseline TBR either unadjusted ( = 0.00, = 1.00) or adjusted for age and baseline calcium volume (beta coefficient = -0.18, = 0.42). TBR at baseline did not differ between participants with ( = 16) compared to those without ( = 5) progression in calcium volume (2.43 ± 0.46 vs. 2.31 ± 0.38, = 0.58). In aortic segments identified to have the highest tracer uptake at baseline, calcium volume did not significantly change over the follow-up period ( = 0.41).
Conclusion: In a cohort of postmenopausal women, F-NaF uptake as measured by TBR in the lumbar aorta did not predict progression of aortic calcification as detected by computed tomography over a four-year follow-up.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506920 | PMC |
| http://dx.doi.org/10.1177/2048004019848870 | DOI Listing |
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