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| http://dx.doi.org/10.4103/jiaps.JIAPS_176_18 | DOI Listing |
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Endothelial cells as key players in cerebral small vessel disease.
Nat Rev Neurosci
January 2025
UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.
Cerebral small vessel disease (SVD) is a vascular disorder that increases the risk of stroke and dementia and is diagnosed through brain MRI. Current primary prevention and secondary treatment of SVD are focused on lifestyle interventions and vascular risk factor control, including blood pressure reduction. However, these interventions have limited effects, a proportion of individuals with sporadic SVD do not have hypertension, and SVD shows strong familial and genetic underpinnings.
View Article and Find Full Text PDFMyocardial perfusion imaging in a case of cardiac strangulation: A novel approach to detect pacemaker-induced ischemia.
Ann Pediatr Cardiol
November 2024
Department of Nuclear Medicine and PET-CT, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.
Cardiac strangulation is a rare phenomenon in children following epicardial pacemaker implantation, caused by compression of the heart and great vessels by the epicardial pacemaker wires. We report a rare case of cardiac strangulation presenting after 8 years of epicardial pacemaker implantation. On routine follow-up, computed tomography angiography showed significant extrinsic compression of the mid-left anterior descending (LAD) artery by the epicardial pacing wire.
View Article and Find Full Text PDFCongenital obstruction of the upper urinary tract is often caused by the pyeloureteral junction syndrome, the lower polar vessel being the most common extrinsic etiology. We report on a case that was successfully treated using the Vascular HITCH, an alternative method with lower morbidity than Anderson and Hynes pyeloplasty considered the gold standard procedure. Our objective is to outline the aforementioned method and illustrate its ease of use and possible efficacy in carefully chosen adult patients.
View Article and Find Full Text PDFRegulation of the blood-brain barrier function by peripheral cues in health and disease.
Metab Brain Dis
December 2024
Institute of Neurology (Edinger Institute), University Hospital, Goethe University Frankfurt, Frankfurt am Main, Germany.
The blood-brain barrier (BBB) is formed by microvascular endothelial cells which are ensembled with pericytes, astrocytes, microglia and neurons in the neurovascular unit (NVU) that is crucial for neuronal function. Given that the NVU and the BBB are highly dynamic and regulated structures, their integrity is continuously challenged by intrinsic and extrinsic factors. Herein, factors from peripheral organs such as gonadal and adrenal hormones may influence vascular function also in CNS endothelial cells in a sex- and age-dependent manner.
View Article and Find Full Text PDFBoth aerosol and primer dimer breakdown for straightforward genotyping based on an integrated immunochromatographic biosensor.
Talanta
November 2024
College of Life Sciences, Northwest University, Xi'an, 710069, China. Electronic address:
Straightforward genotyping can provide timely diagnostic information for diseases prevention and treatment. Taking advantages of speediness and convenience, although numerous genotyping strategies combined loop-mediated isothermal amplification (LAMP) and lateral flow have been reported to satisfy the demand of point-of-care test, the false positive result caused by aerosol and primer dimer as an innate conflict seriously limits their practical application. In this study, both aerosol and primer dimer as extrinsic and intrinsic inducements respectively are first broken through at one stroke based on an integrated immunochromatographic biosensor.
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