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Two different pathways for the synthesis of annulated pyrido[3,4-]indoles are reported using metal-catalyzed cyclotrimerization reactions. A stepwise process using Rh(I)-catalysis in the final step of the synthesis and a multicomponent, tandem catalytic approach using Pd(0)-catalysis both lead to complex nitrogen-containing heterocycles in good yields. Substituent effects are investigated for both pathways, demonstrating that the Pd(0)-catalyzed approach is more sensitive to electron- withdrawing groups.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519955 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2018.10.050 | DOI Listing |
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