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Ultrastructure and three-dimensional architecture of the anterior cruciate ligament in the knee joints of young and old monkeys. | LitMetric

Ultrastructure and three-dimensional architecture of the anterior cruciate ligament in the knee joints of young and old monkeys.

Med Mol Morphol

Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, 1-1 Idaigaoka Hasama-machi, Yufu, Oita, 879-5593, Japan.

Published: March 2020

AI Article Synopsis

  • The study analyzed the structure of the anterior cruciate ligament (ACL) in young and old monkeys using advanced microscopy techniques to observe changes due to aging.
  • In young monkeys, the ACL had active fibroblasts producing tightly packed collagen fibrils, while in older monkeys, a decrease in fibroblast numbers and atrophy led to a looser configuration of collagen.
  • These findings indicate that age-related changes in the ACL structure may explain the reduced repair ability and deterioration observed in human ligaments as they age.

Article Abstract

We examined the ultrastructure of the anterior cruciate ligament and assessed age-related changes by comparing the ligaments of young and old monkeys. Ultrathin sections of the anterior cruciate ligament were observed by transmission electron microscopy. The three-dimensional architecture of collagen fibers in the ligament was examined by scanning electron microscopy after tissue specimens were treated with 2 N NaOH to digest the extracellular matrix. At the surface layer of the cruciate ligament in young monkeys, fusiform-shaped fibroblasts actively produced collagen fibrils. The ligament consisted of parallel bundles of dense collagen fibrils of approximately 200 nm in diameter. Collagen fibrils appeared to run linearly. Ligament fibrocytes in the deep layer had a stellate form. Ligament fibrocytes decreased in number and showed marked atrophy in old age. Collagen fibrils had a looser configuration in older monkeys. Despite atrophy of fibroblasts in the deep layer of the anterior cruciate ligament, the area with atrophic fibroblasts in the ligament expands with age, which can likely cause deterioration of and a reduction in collagen fibers. This information can be applied in studies on the cause of the low repair ability of and aging-related changes in the anterior cruciate ligament in humans.

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Source
http://dx.doi.org/10.1007/s00795-019-00224-7DOI Listing

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