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MTGGF: A Metabolism Type-Aware Graph Generative Model for Molecular Metabolite Prediction.
Interdiscip Sci
January 2025
School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China.
Metabolism in vivo turns small molecules (e.g., drugs) into metabolites (new molecules), which brings unexpected safety issues in drug development.
View Article and Find Full Text PDFThe Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID-19 Pandemic.
Pediatr Pulmonol
January 2025
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Background: Respiratory syncytial virus (RSV) infection in the first year of life has been linked with an increased risk for asthma. Some propose that RSV-induced inflammation leads to lasting airway changes, while others contend that RSV bronchiolitis is a marker for underlying predisposition. Social distancing adopted during the COVID-19 pandemic has led to a dramatic reduction in RSV activity, providing an unexpected opportunity to investigate this debate.
View Article and Find Full Text PDFAmniotic Fluid Embolism After Cervical Ripening.
Cureus
December 2024
Obstetrics, Orlando Regional Medical Center, Orlando, USA.
Amniotic fluid embolism (AFE) is a rare condition that can have catastrophic maternal and infant consequences. It can lead to rapid multisystem failure and is responsible for a significant portion of maternal deaths. The diagnosis is frequently made late in the pathological process, and the treatment is mainly supportive and infant delivery.
View Article and Find Full Text PDFBeyond CTLA-4 and PD-1: Novel Insights into MAO-A as a Next- Generation Immune Checkpoint Modulator for Cancer Immunotherapy.
Curr Cancer Drug Targets
January 2025
Division of Pharmacology, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, 700114, India.
Immune checkpoint blockade (ICB) has fundamentally transformed cancer treat-ment by unlocking the potency of CD8+ T cells by targeting the suppression of the CTLA-4 and PD-1/PD-L1 pathways. Nevertheless, ICBs are associated with the risk of severe side effects and resistance in certain patients, driving the search for novel and safer immune check-point modulators. Monoamine Oxidase A (MAO-A) plays an unexpected role in the field of cancer.
View Article and Find Full Text PDFMidwives' experience of managing emergencies during labour and birth in a community setting: a mixed-methods systematic review.
Women Birth
January 2025
National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford. Electronic address:
Background: For women at low risk of complications during labour and birth, in the United Kingdom, planned birth in a 'community' setting (at home or a freestanding midwifery unit) is generally safe, and intrapartum emergencies are uncommon. Limited exposure may affect midwives' experience of managing an emergency.
Aim: Identify and synthesise available evidence about midwives' experiences of managing intrapartum emergencies during labour in a community setting.
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