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Backtrace:
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File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Backtrace:
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Severity: Warning
Message: Trying to access array offset on value of type null
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Severity: Warning
Message: Trying to access array offset on value of type null
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Filename: models/Detail_model.php
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File: /var/www/html/application/models/Detail_model.php
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Filename: helpers/my_audit_helper.php
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Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
File: /var/www/html/application/controllers/Detail.php
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Filename: controllers/Detail.php
Line Number: 256
Backtrace:
File: /var/www/html/application/controllers/Detail.php
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Severity: Warning
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Severity: Warning
Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
Ca signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells. | LitMetric
Endothelin type A receptor (ETR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETR expressed in Chinese hamster ovary cells. ET-1 elicited ETR internalization and increase in intracellular Ca concentration. ET-1-induced ETR internalization was completely inhibited by a reduction in intracellular and extracellular Ca levels and partially suppressed by inhibitors of protein kinase C (PKC) and extracellular signal-regulated kinases 1/2 (ERK1/2), both of which are downstream molecules in ETR signaling. These results suggest that Ca mobilization, PKC, and ERK1/2 are involved in ET-1-induced ETR internalization.
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