AI Article Synopsis
- Mapuche Amerindians, found in Central South Chile and Argentina, speak the unclassified language "Mapudungun."
- A study of Chilean Mapuche focused on HLA genes revealed typical Amerindian genes shared with Pacific Islanders, highlighting potential genetic connections.
- The findings suggest historical cultural and genetic exchanges between the Americas and Pacific regions, indicating a need to reassess how the Americas were populated and offering insights for medical applications in transplantation and disease epidemiology.
Article Abstract
Mapuche Amerindians live now widespread in Central South Chile and Argentina and speak "Mapudungun", an unclassified language. A group of Chilean Mapuche was studied for HLA genes using standard techniques. Typical Amerindian HLA genes and haplotypes are found in the population, like HLA-DRB1*14:02, -08:02 and class II haplotype DRB1*08:02-DQB1*04:02. However, these and other genes are also common in Pacific Islanders. Thus, relatedness of First America Inhabitants with some Pacific Islanders is stressed. Evidences of Pacific and Atlantic cultural and genetic exchange, probably in both directions, and California Man settlements found since 130,000 years ago makes it necessary a revision of Americas peopling. This study may be also useful for medical Mapuche use in Transplantation and HLA and disease Epidemiology.
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| http://dx.doi.org/10.1016/j.humimm.2019.04.015 | DOI Listing |
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