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secukinumab hiv-positive
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Article Synopsis
- - Psoriasis is a long-term inflammatory skin condition linked to T-lymphocyte activation, and treating it in individuals with HIV is challenging due to immune system complications.
- - This study reviewed 19 articles involving 24 cases of psoriasis in people with HIV, analyzing various therapies like apremilast and ustekinumab, which showed effectiveness in reducing skin symptoms and even some cases of psoriatic arthritis.
- - Although adverse events were rare and manageable, more comprehensive research is needed to clearly understand the safety and efficacy of these treatments for HIV-positive patients.
Clin Cosmet Investig Dermatol
December 2022
Department of Integrated Traditional Chinese and Western Medicine of Dermatology, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People's Republic of China.
Psoriasis is an immune-mediated chronic inflammatory dermatosis influenced by hereditary and environmental factors. Human immunodeficiency virus (HIV) infection affects the immune system and exacerbates psoriatic lesions. We report the case of a 33-year-old male patient diagnosed with psoriasis vulgaris, psoriatic arthritis and HIV infection.
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Objective: This study examined the safety and efficacy of biological agents, especially tumour necrosis factor (TNF) inhibitors, for HIV-positive rheumatology patients refractory to standard therapy.
Methods: This study is a retrospective case series including patients derived from a community HIV clinic as well as from two academic centres. Initial visit data collected included: sociodemographic characteristics, CD4 counts, HIV viral load and medication use.
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Front Med (Lausanne)
December 2021
Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Inactivated Sinovac-CoronaVac vaccine (Sinovac Life Sciences, Beijing) for coronavirus disease 2019 (COVID-19) has been used in many countries. However, its immunogenicity profile in immunosuppressed dermatological patients is lacking. This prospective observational case-control study compared the humoral immune response between adult dermatological patients receiving systemic immunosuppressive therapies ( = 14) and those who did not ( = 18); excluding patients with HIV infection, cancer, non-dermatological autoimmune conditions, previous COVID-19 infection, and positive anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG prior to vaccination.
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