Purpose: Extrapulmonary infections due to M. xenopi, particularly osteoarticular localizations, are rare. The purpose of this paper is to describe a case of prosthetic hip infection and to review the published literature on cases of M. xenopi osteoarticular infections.
Methods: Literature search was performed in the following databases: MEDLINE (PubMed), Embase, Central (the Cochrane Library 2019, Issue 1), LILACS (BIREME) (Latin American and Caribbean Health Science Information database) and Clinical Trials databases (14th August 2018). We included all case reports and case series on adult patients diagnosed with bone or joint infection by M. xenopi for whom the treatment and outcome were specified.
Results: We retrieved 30 cases published between 1982 and 2012, among which 25 (83.3%) were reported from Europe. The two most common infection sites were spine (12/30, 40%) and knee (9/30, 30%). Risk factors for infection were previous invasive procedures (11/30, 36.7%), autoimmune disease (8/30, 26.7%), AIDS (4/30, 13.3%) and other comorbidities (2/30, 6.7%); five patients had no past medical history. All patients were treated with antibiotic combinations, but composition and duration of regimens hugely varied. Surgical intervention was performed in 16 patients (53.3%). Only 11 patients obtained full recovery of articular mobility after treatment.
Conclusion: This work highlights the difficulties in diagnosing and treating M. xenopi osteoarticular infections. Globally, evidence supporting the best practice for diagnosis and treatment of this infection is scanty.
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http://dx.doi.org/10.1007/s15010-019-01318-1 | DOI Listing |
Infection
April 2020
Dipartimento di Malattie Infettive-Tropicali e Microbiologia, Centro per le Malattie Tropicali, IRCCS Ospedale Sacro Cuore Don Calabria, Via Sempreboni 5, 37024, Negrar, Verona, Italy.
Purpose: Extrapulmonary infections due to M. xenopi, particularly osteoarticular localizations, are rare. The purpose of this paper is to describe a case of prosthetic hip infection and to review the published literature on cases of M.
View Article and Find Full Text PDFClin Infect Dis
October 2006
Department of Internal Medicine and Rheumatology, Diaconesses-Croix-Saint-Simon Hospital, Paris, 75020, France.
Background: Mycobacterium xenopi is a nontuberculous mycobacterium responsible for opportunistic and nosocomial infections, chiefly of the lung; few cases of bone and joint infection have been reported. From July 1989 through May 1993, an outbreak of 58 cases of nosocomial discitis due to M. xenopi infection following percutaneous nucleotomy occurred in a French hospital.
View Article and Find Full Text PDFPresse Med
March 2000
Service de Médecine interne et maladies infectieuses, Centre hospitalier de Troyes.
Background: Mycobacterium xenopi is an uncommon cause of osteoarticular sepsis. However, a recent series of M. xenopi spondylodiscitis emphasizes the potential risk after invasive procedures.
View Article and Find Full Text PDFPresse Med
November 1998
Service de Rhumatologie, Hôpital de Bellevue, CHU de Saint-Etienne.
Background: Mycobacterium xenopi is a potential pathogen for man and can cause bone and joint infections, particularly spondylodiscitis. Most cases of infection occur in fragilized patients and are found more and more often in AIDS patients.
Case Report: A 41-year-old HIV+ woman developed cervical spondylodiscitis due to Mycobacterium xenopi infection.
J Rheumatol
May 1998
Department of Medicine, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
Osteoarticular Mycobacterium xenopi infections are very rare. We describe a patient with dermatomyositis and isolated shoulder arthritis due to M. xenopi.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!