Healthcare systems worldwide face the challenge of recognising and improving safety, timeliness, quality and productivity. The authors describe how the COM-B model, developed by Michie et al in 2011 to explain and change criminal behaviour, is useful in identifying what skills and capabilities healthcare providers require to improve their systems. These skills include the intellectual capability to understand, design and improve healthcare processes; the opportunity to do this in their daily work; the motivation to do this - in particular recognising the reasons not to change; and finally unlearning the behaviours based on historical system beliefs that are now invalid. Individual self-awareness and organisational leadership are required to give staff the time and resources to reflect, experiment and learn.
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http://dx.doi.org/10.7861/futurehosp.3-3-188 | DOI Listing |
J Orthop Surg Res
January 2025
Monash Suzhou Research Institute, Monash University, Suzhou, 215000, Jiangsu, China.
Backgrounds: Osteoarthritis (OA) significantly impacts the elderly, leading to disability and decreased quality of life. While hyaluronic acid (HA) and chondroitin sulfate (CS) are recognized for their therapeutic potential in OA, their effects on extracellular matrix (ECM) degradation are not well understood. This study investigates the impact of HA and CS, individually and combined, on ECM degradation in OA and the underlying mechanisms.
View Article and Find Full Text PDFBMC Bioinformatics
January 2025
MOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
Background: CRISPRi screening has become a powerful approach for functional genomic research. However, the off-target effects resulting from the mismatch tolerance between sgRNAs and their intended targets is a primary concern in CRISPRi applications.
Results: We introduce Guide Library Designer (GLiDe), a web-based tool specifically created for the genome-scale design of sgRNA libraries tailored for CRISPRi screening in prokaryotic organisms.
Sci Rep
January 2025
College of Intelligent systems Science and Engineering, Harbin Engineering University, Harbin, 150006, China.
Most of toolpaths for machining is composed of series of short linear segments (G01 command), which limits the feedrate and machining quality. To generate a smooth machining path, a new optimization strategy is proposed to optimize the toolpath at the curvature level. First, the three essential components of optimization are introduced, and the local corner smoothness is converted into an optimization problem.
View Article and Find Full Text PDFAdvanced practice providers (APPs) experience limited clinical opportunities to perform neonatal procedures to maintain competency and hospital credentialing, especially high-acuity procedures that are extremely rare but crucial during patient emergencies. Incorporating simulation as part of continuing professional education can help APPs maintain clinical procedural competency and learn new procedural techniques to improve the quality and safety of procedures performed in the clinical setting. In 2013, we successfully developed and implemented an annual didactic and simulation-based neonatal procedural skills program.
View Article and Find Full Text PDFJ Med Internet Res
December 2024
Guangzhou Cadre and Talent Health Management Center, Guangzhou, China.
Background: Large language models have shown remarkable efficacy in various medical research and clinical applications. However, their skills in medical image recognition and subsequent report generation or question answering (QA) remain limited.
Objective: We aim to finetune a multimodal, transformer-based model for generating medical reports from slit lamp images and develop a QA system using Llama2.
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