The nonpsychoactive phytocannabinoid, CBD, was recently approved by the Food and Drug Administration for the treatment of children with drug-resistant epilepsy. This milestone opens new avenues for cannabinoid research. In this Viewpoint, we provide an overview of recent progress in the field highlighting molecular insights into CBD's mechanism of action, as well as its therapeutic potential.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511966 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.9b00127 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABA receptors.
Fundam Res
November 2024
State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
The approval of Epidiolex, an anti-epileptic drug containing cannabidiol (CBD) as its active component, has brought hope to patients with refractory epilepsy. However, the anti-seizure effect of full-spectrum hemp extract (HE), a CBD-enriched hemp oil, remains unclear. In this study, we investigated the anti-seizure effect of HE using drug-induced seizure models.
View Article and Find Full Text PDFCharacteristics for Medical Cannabis Treatment Adherence among Autistic Children and Their Families: A Mixed-Methods Analysis.
Med Cannabis Cannabinoids
April 2024
Department of Occupational Therapy, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.
Introduction: Medical cannabis treatment for autistic children has recently become popular, and studies have focused on examining the treatment's effects on children's symptom presentation, reported side effects, and dropout rates. However, no previous study has investigated the factors influencing adherence and dropout rates in cannabis treatment.
Method: This explanatory sequential mixed-methods study explored these factors by examining the characteristics of 87 autistic children and their families and deepening parents' perspectives and experiences of the 6-month CBD-rich cannabis treatment's benefits and barriers.
Prevalence of Dietary Modification and Supplement Use in Patients with Metastatic Renal Cell Carcinoma Receiving Systemic Therapy.
Nutrients
May 2024
Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Article Synopsis
- - A study assessed dietary changes and supplement use among patients with metastatic renal cell carcinoma, finding that 50.9% of respondents began using supplements post-diagnosis, with probiotics and CBD being the most popular.
- - The survey, conducted by KCCure, gathered data from 289 patients on their dietary patterns, supplement expenses, and perceptions of alternative medicine.
- - Results indicated that 34.9% of patients made dietary modifications, predominantly adopting the Mediterranean and ketogenic diets, highlighting the need for doctors to discuss supplement use with their patients as these practices may influence cancer treatment outcomes.
Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use.
Int J Mol Sci
April 2024
Pharmaceutical and Therapeutic Chemistry Department, Faculty of Pharmacy, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mures, Romania.
Phytocannabinoids, a diverse group of naturally occurring compounds extracted from the plant, have attracted interest due to their potential pharmacological effects and medicinal uses. This comprehensive review presents the intricate pharmacological profiles of phytocannabinoids while exploring the diverse impacts these substances have on biological systems. From the more than one hundred cannabinoids which were identified in the plant so far, cannabidiol (CBD) and tetrahydrocannabinol (THC) are two of the most extensively studied phytocannabinoids.
View Article and Find Full Text PDFCannabinoids and Sleep: Exploring Biological Mechanisms and Therapeutic Potentials.
Int J Mol Sci
March 2024
Psychiatry Unit, Department of Health Sciences, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy.
The endogenous cannabinoid system (ECS) plays a critical role in the regulation of various physiological functions, including sleep, mood, and neuroinflammation. Phytocannabinoids such as Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinomimimetics, and some N-acylethanolamides, particularly palmitoyethanolamide, have emerged as potential therapeutic agents for the management of sleep disorders. THC, the psychoactive component of cannabis, may initially promote sleep, but, in the long term, alters sleep architecture, while CBD shows promise in improving sleep quality without psychoactive effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!