Securing the future of research computing in the biosciences.

PLoS Comput Biol

Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.

Published: May 2019

Improvements in technology often drive scientific discovery. Therefore, research requires sustained investment in the latest equipment and training for the researchers who are going to use it. Prioritising and administering infrastructure investment is challenging because future needs are difficult to predict. In the past, highly computationally demanding research was associated primarily with particle physics and astronomy experiments. However, as biology becomes more quantitative and bioscientists generate more and more data, their computational requirements may ultimately exceed those of physical scientists. Computation has always been central to bioinformatics, but now imaging experiments have rapidly growing data processing and storage requirements. There is also an urgent need for new modelling and simulation tools to provide insight and understanding of these biophysical experiments. Bioscience communities must work together to provide the software and skills training needed in their areas. Research-active institutions need to recognise that computation is now vital in many more areas of discovery and create an environment where it can be embraced. The public must also become aware of both the power and limitations of computing, particularly with respect to their health and personal data.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521984PMC
http://dx.doi.org/10.1371/journal.pcbi.1006958DOI Listing

Publication Analysis

Top Keywords

securing future
4
future computing
4
computing biosciences
4
biosciences improvements
4
improvements technology
4
technology drive
4
drive scientific
4
scientific discovery
4
discovery requires
4
requires sustained
4

Similar Publications

Rural first-generation college students (FGCS) face significant barriers as they transition into the world of work, yet no studies have explored their career development using psychology of working theory (PWT). The present study aimed to examine the predictor and outcome portions of PWT with a sample of FGCS from rural China. We administered online surveys to 549 participants and employed structural equation modeling to analyze the data.

View Article and Find Full Text PDF

Modernizing power systems into smart grids has introduced numerous benefits, including enhanced efficiency, reliability, and integration of renewable energy sources. However, this advancement has also increased vulnerability to cyber threats, particularly False Data Injection Attacks (FDIAs). Traditional Intrusion Detection Systems (IDS) often fall short in identifying sophisticated FDIAs due to their reliance on predefined rules and signatures.

View Article and Find Full Text PDF

Using machine learning to forecast peak health care service demand in real-time during the 2022-23 winter season: A pilot in England, UK.

PLoS One

January 2025

Real-time Syndromic Surveillance Team, Field Services, Health Protection Operations, UK Health Security Agency, Birmingham, United Kingdom.

During winter months, there is increased pressure on health care systems in temperature climates due to seasonal increases in respiratory illnesses. Providing real-time short-term forecasts of the demand for health care services helps managers plan their services. During the Winter of 2022-23 we piloted a new forecasting pipeline, using existing surveillance indicators which are sensitive to increases in respiratory syncytial virus (RSV).

View Article and Find Full Text PDF

Molecular Mechanism Behind the Capture of Fluorinated Gases by Metal-Organic Frameworks.

Nanomicro Lett

January 2025

College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Siping Rd 1239, Shanghai, 200092, People's Republic of China.

Fluorinated gases (F-gases) play a vital role in the chemical industry and in the fields of air conditioning, refrigeration, health care, and organic synthesis. However, the direct emission of waste gases containing F-gases into the atmosphere contributes to greenhouse effects and generates toxic substances. Developing porous materials for the energy-efficient capture, separation, and recovery of F-gases is highly desired.

View Article and Find Full Text PDF

Halide perovskites, a game changer for future medical imaging technology.

Biophys Rev (Melville)

March 2025

School of Physics, Australian Centre for Microscopy and Microanalysis, Sydney Nano Institute, The University of Sydney, Sydney, NSW 2006, Australia.

The accurate detection of x-rays enables broad applications in various fields, including medical radiography, safety and security screening, and nondestructive inspection. Medical imaging procedures require the x-ray detection devices operating with low doses and high efficiency to reduce radiation health risks, as well as expect the flexible or wearable ones that offer more comfortable and accurate diagnosis experiences. Recently, halide perovskites have shown promising potential in high-performance, cost-effective x-ray detection owing to their attractive features, such as strong x-ray absorption, high-mobility-lifetime product, tunable bandgap, fast response, as well as low-cost raw materials, facile processing, and excellent flexibility.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!