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Why implementing machine learning algorithms in the clinic is not a plug-and-play solution: a simulation study of a machine learning algorithm for acute leukaemia subtype diagnosis.
EBioMedicine
December 2024
Department of Haematology & Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany; Laboratory for Clinical Research and Real-World Evidence, Institute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany. Electronic address:
Article Synopsis
- The study evaluated the performance of the AI-PAL machine learning algorithm for diagnosing acute leukaemia when implemented in a real-world clinical setting at the University Hospital Essen.
- Results showed that the AI-PAL algorithm performed significantly worse in the clinical simulation compared to previous results, with key performance metrics falling below the expected levels.
- The findings highlight the necessity for local validation and potential recalibration of machine learning models before their use in clinical settings to ensure they are reliable and safe for patient care.
Genetic variants in PIKFYVE: A review of ocular phenotypes.
Exp Eye Res
December 2024
Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Canada. Electronic address:
Article Synopsis
- A review highlights various disease-causing variants of the gene PIKFYVE found in ocular tissues and their associated eye conditions, filling a gap in existing research.
- PIKFYVE is important for regulating cellular functions like autophagy and phagocytosis, and variants in this gene are linked to conditions like corneal fleck dystrophy and congenital cataracts.
- The study aims to establish possible connections between specific genetic variants and the eye disorders they cause, which could help improve future diagnosis and treatment of PIKFYVE-related ocular diseases.
Reflux Disease in Singers: A Systematic Review.
J Voice
December 2024
Department of Computational Medicine and Neuropsychiatry, Faculty of Medicine, University of Mons, Mons, Belgium; Department of Clinical Sciences, Faculty of Medicine, University of Liège, Liège, Belgium.
Objective: To investigate the laryngopharyngeal reflux disease (LPRD) features in singers.
Methods: According to the PRISMA statements, two investigators searched the literature related to the prevalence of symptoms, findings, and clinical therapeutic outcomes of reflux in singers through a PubMed, Scopus, and Cochrane Library systematic review.
Results: Of the 91 identified studies, 18 publications met the inclusion criteria, accounting for 2288 singers and 1398 controls, respectively.
A comprehensive review and meta-analysis of CTC isolation methods in breast cancer.
Crit Rev Oncol Hematol
November 2024
Institute of Molecular Theranostics, Sechenov First Moscow State Medical University, Moscow 119991, Russia; School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.
The application of circulating tumor cells (CTCs) as diagnostic and prognostic markers in oncology is gaining increasing importance in clinical practice. Currently, various methods exist for detecting CTCs in patients' biological fluids. This systematic review aimed to compare the efficacy of different techniques for isolating and detecting CTCs from blood, against the FDA-cleared CellSearch® technology, in breast cancer patients.
View Article and Find Full Text PDFPerformance of the comprehensive nutrition screening index in predicting mortality after cardiac surgery.
Sci Rep
November 2024
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
Malnutrition is a significant risk factor for postoperative outcomes in patients undergoing cardiac surgery. The Seoul National University Hospital-Nutrition Screening Index (SNUH-NSI) is an automated screening tool designed to comprehensively assess malnutrition risk. However, its predictive value in patients undergoing cardiac surgery remains unvalidated.
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