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Yield of clinical metagenomics: insights from real-world practice for tissue infections.
EBioMedicine
December 2024
Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, PR China; Zhejiang Key Laboratory of Clinical in Vitro Diagnostic Techniques, Hangzhou, 310003, PR China; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, 310003, PR China. Electronic address:
Background: While metagenomic next-generation sequencing (mNGS) has been acknowledged as a valuable diagnostic tool for infections, its clinical validity and impact on patient management when using fresh tissue samples remains uncertain.
Methods: We conducted a retrospective cross-sectional study involving patients who underwent tissue mNGS at a tertiary hospital in China from February 2021 to February 2024, aiming to assess its ability to detect plausible pathogens and its clinical validity and impact.
Findings: A total of 520 mNGS results from 508 patients were analysed, detecting plausible pathogens in 302 (58.
First metagenomic sequencing for the analysis of microbial community populations of adults and pupae of in Xinjiang, China.
Front Vet Sci
December 2024
College of Animal Science and Technology, Tarim University, Alar, China.
Introduction: , a parasite on the body surface of sheep, directly attacks the host through biting and sucking blood and may also transmit pathogens in the process. There are currently only a few studies on the microbial composition of , while there are no such studies on pupae.
Methods: In this study, samples AT-1 to AT-4 each contained four individuals, while sample AT-5 comprised four pupae, all used for metagenomic sequencing and analysis.
Cat scratch disease in children with nocturnal fever: A case report.
World J Clin Cases
December 2024
Department of Pediatric Intensive Care Unit, Rainbow Hospital of Xianyang (Children's Hospital of Xianyang), Xianyang 721000, Shaanxi Province, China.
Background: Cat scratch disease (CSD) is the most common human infection caused by (). The main manifestation is self-limited lymphadenopathy that primarily affects adolescents, and typically resolves without treatment within 2-4 months. However, individuals with compromised immune systems or immunodeficiency require specific antibacterial therapy following diagnosis.
View Article and Find Full Text PDFMolecular investigation of Coxiella burnetii and Bartonella in heart valve specimens of patients with endocarditis in Iran.
J Infect Public Health
January 2025
National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran; Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:
Article Synopsis
- Infective endocarditis (IE) is a serious health issue, and this study investigates the presence of Coxiella burnetii and Bartonella spp. in heart valves in Iran.
- The research examined 146 patients who had heart valve surgery and found C. burnetii in 12 patients and Bartonella quintana in 15 patients, with two new C. burnetii genotypes identified.
- The study suggests that more research is needed to improve prevention, diagnosis, and treatment methods for Q fever endocarditis and Bartonella endocarditis.
Performance of metagenomic next-generation sequencing for microbiological diagnosis of infectious uveitis.
J Med Microbiol
December 2024
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Diagnosis of uveitis is challenging due to the multitude of possible pathogenies. Identifying infectious and non-infectious uveitis is of great clinical significance. Recently, metagenomic next-generation sequencing (mNGS) was used to detect infectious and non-infectious uveitis, but its efficacy has not been widely evaluated.
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