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ERBB2/ERBB3-mutated S100/SOX10-positive uterine sarcoma: something new.
Virchows Arch
December 2024
Department of Pathology, University of California San Diego Health, 9300 Campus Point Drive, Suite 1-200, La Jolla, MC 7723, San Diego, CA, 92037, USA.
A distinctive subset of uterine mesenchymal tumors display recurrent genetic fusions involving receptor tyrosine kinases, including NTRK, PDGFB, FGFR1, and RET, presumably leading to aberrant pathway activation. A pair of recent studies have highlighted the existence of a genetic fusion-negative uterine sarcoma that is characterized by activating mutations in ERBB2/ERBB3, CDKN2A deletion, inactivating ATRX mutation, and a S100 + /SOX10 + immunohistochemical profile. This report describes another case of this emerging entity that was diagnosed in a 57-year-old woman.
View Article and Find Full Text PDFImprovement of tumor-to-blood ratio of radioimmunoconjugates by poly(ethyleneimine)-containing chelating agent.
Ann Nucl Med
November 2024
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Objective: Monoclonal antibody (mAb)-based radioimmunoconjugates (RICs) exhibit marked tumor uptake in cancer imaging and therapy, although their high blood retention has limited the development of RICs. In our previous study, a trifunctional chelating agent with a cationic poly(ethyleneimine) (PEI) structure of tetraethylenepentamine (PEI4), maleimide-DOTA-PEI4 (MDI4), improved the tumor-to-blood ratio of RICs by increasing tumor retention compared with a conventional bifunctional chelating agent. In this study, we developed a novel chelating agent composed of a maleimide moiety, DOTA derivative, and two PEI4 structures as a PEI4-2 unit, maleimide-DOTA-PEI4-2 (MDI4-2), a design for a highly cationized chelating agent to synthesize RICs.
View Article and Find Full Text PDFBlastic plasmacytoid dendritic cell neoplasm of skin, a rare dermatohematologic malignancy-A case report.
Clin Case Rep
September 2024
Department of Pathology, School of Medicine, Imam Khomeini Hospital Tehran University of Medical Sciences Tehran Iran.
Article Synopsis
- Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive form of blood cancer that poses diagnostic challenges for both clinicians and pathologists.
- A case study of a 71-year-old man with an ulcerated skin lesion illustrates key histopathological features, including atypical cells that test positive for specific markers, confirming BPDCN.
- The condition often presents with skin involvement characterized by purplish nodules and requires differentiation from similar conditions, emphasizing the need for pathologists to be aware of this rare malignancy for prompt diagnosis.
Microscopic structure and immunolabeling of extremely overlapped scales in some scincid, anguid, and pygopod lizards.
Protoplasma
January 2025
Comparative Histolab Padova, Padua, Italy.
Skink, anguid, and pygopod lizards possess an extremely flat skin, imparting a compact and solid body and shining surface that facilitates their slider and/or fossorial movements. The present morphological study, conducted using immunohistochemistry and electron microscopy, has analyzed the microscopical morphology of extremely overlapped scales in different lizards, including species with limb reduction (scincids such as Lerista bougainvilli, Scincella lateralis, Lampropholis delicata) or legless (pygopods such as Lialis burtonis and Delma molleri and the anguid Anguis fragilis). The outer surface of the epidermis shows different micro-structures of the Oberhautchen layer containing corneous beta-proteins (CBPs) with variable immunoreactivity for these proteins.
View Article and Find Full Text PDFA Comparison of Immunohistochemical Expression of Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 in Dental Follicles with Different Radiographic Sizes.
Iran J Med Sci
August 2024
Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
Background: Odontogenic cysts and tumors develop from the dental follicle of asymptomatic impacted teeth. Odontogenic tissues express the epidermal growth factor receptor family (EGFR), which mediates cell proliferation, survival, and neoplastic differentiation. The present study aimed to compare the immunohistochemical expression of EGFR and human epidermal growth factor receptor 2 (HER2) in the dental follicle of impacted wisdom teeth with normal and abnormal radiographic size.
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