The effect of item-based directed forgetting (DF) on recognition memory for categorized word lists was examined. For half of the categories, all studied exemplars were followed by a remember cue; for the other half of the categories, all studied exemplars were followed by a forget cue. In Experiment 1, a 2-alternative forced-choice recognition test showed decreased recognition for to-be-forgotten items. This effect was seen both when the distractor was from the same category as the target requiring discrimination be based on memory for the specific studied exemplars (exemplar test condition) and when the distractor was from a novel category and discrimination could be based on memory for the studied categories (category test condition). In Experiment 2, a yes-no recognition test showed a DF effect not only in higher hit rates for remember-cued targets compared to forget-cued targets, but also in higher false alarm rates for new exemplars from remember-cued compared to forget-cued categories. The effects of intentional forgetting of categorized word lists are seen not only for the studied exemplars but also for the studied categories and the unstudied typical exemplars of these categories. These results pose a theoretical challenge for the attentional inhibition account of DF. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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Appl Environ Microbiol
December 2024
Michael Smith Laboratories, The University of British Columbia, Vancouver, British Columbia, Canada.
Unlabelled: There is growing interest in members of the genus (family ) as members of a well-balanced human gut microbiota (HGM). are particularly associated with the consumption of a diet rich in plant polysaccharides comprising dietary fiber. However, understanding of the molecular basis of complex carbohydrate utilization in species is currently incomplete.
View Article and Find Full Text PDFJ Am Soc Mass Spectrom
January 2025
Michael Barber Centre for Collaborative Mass Spectrometry, MBCCMS, Princess Street, Manchester M17DN, U.K.
Post expression from the host cells, biotherapeutics undergo downstream processing steps before final formulation. Mass spectrometry and biophysical characterization methods are valuable for examining conformational and stoichiometric changes at these stages, although typically not used in biomanufacturing, where stability is assessed via bulk property studies. Here we apply hybrid MS methods to understand how solution condition changes impact the structural integrity of a biopharmaceutical across the processing pipeline.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Humanities & Social Sciences, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Fear generalization plays a major role in the acquisition and maintenance of anxiety disorders. In fear generalization, conditioned fear responses are observed for novel stimuli sharing perceptually or conceptually similar properties with the conditioned stimulus (CS). The reinforcement rates of the unconditioned stimulus (UCS) impact fear acquisition and generalization.
View Article and Find Full Text PDFAnalyst
November 2024
Process Instruments, Turf Street, Burnley, Lancashire, BB11 3BP, UK.
The most common methodology for performing multiple chemical and biological reactions in parallel is to use microtitre plates with either manual or robotic dispensing of reactants and wash solutions. We envision a paradigm shift where acoustically levitated droplets serve as wells of microtitre plates and are acoustically manipulated to perform chemical and biological reactions in a non-contact fashion. This in turn requires that lines of droplets can be levitated and manipulated simultaneously so that the same operations (merge, mix, and detect) can be performed on them in parallel.
View Article and Find Full Text PDFAust Health Rev
December 2024
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
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