Background: The use of anti-epileptic drugs for prophylaxis of early post-traumatic seizures after traumatic brain injury has been very promising. The objective of this study was to determine the outcome of phenytoin in prevention of early post-traumatic seizures in moderate to severe traumatic brain injuries and to compare the frequency of seizures in moderate to severe traumatic brain injury, with phenytoin started within 12 hours and after 12 hours of injury.
Methods: This cross-sectional study was conducted at Department of Neurosurgery, Ayub Medical Institute, Abbottabad from April to October, 2015. All the patients with moderate to severe head injury presenting within 48 hours of injury were included in this study in consecutive manner. Patients were started on phenytoin and observed for early post-traumatic seizures.
Results: A total of 163 patients were included in this study with a mean age of 24.69±10.186 years. One hundred and twenty-two (74.8%) were males and rest of 41 (25.2%) were females. A total of 26 (16%) patients had early post-traumatic seizures. 9.89% patients in whom phenytoin was started within 12 hours had seizures, while 23.11% patients in whom phenytoin was started after 12 hours of injury had seizures, the difference being statistically significant (p-value .018)..
Conclusions: Frequency of early post-traumatic seizures is high in patients with moderate to severe head injured patients. Anti-epileptics like phenytoin should be started within 12 hours for seizure prophylaxis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Experience of post-traumatic growth among parents of children with biliary atresia undergoing living-related liver transplantation: a descriptive phenomenological study.
Eur J Psychotraumatol
December 2025
Department of Nursing, the First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, People's Republic of China.
To explore the experience of post-traumatic growth among parents of children with biliary atresia undergoing living-related liver transplantation.: Participants were recruited within 2 weeks of their child's transplant surgery using purposive sampling. Transcripts were analyzed using Colaizzi's descriptive analysis framework, with collaborative analysis conducted using NVivo 12 software and a post-traumatic growth model.
View Article and Find Full Text PDFValidation of the Perceived hope scale in Arabic-speaking adults living in Gaza in the midst of war, destruction and death.
Arch Public Health
January 2025
School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, P.O. Box 446, Jounieh, Lebanon.
Background: Despite its obvious relevance for clinical practice and research, it is surprising that presently no hope measure is available for use among Arabic-speaking populations, especially the most vulnerable ones who have been going through major humanitarian crises. This paper aimed to provide novel insights into psychometric information on the psychometric properties of an Arabic translation of the Perceived Hope Scale (PHS) in Palestinians living in Gaza who have endured several months of suffering since the war began in October 2023.
Method: This study had a cross-sectional design and applied a quantitative research approach.
Trauma echoes: factors associated with peritraumatic distress and anxiety five days following Iranian missile attack on Israel.
Eur J Psychotraumatol
December 2025
Department of Gerontology, University of Haifa, Haifa, Israel.
On 13-14 April 2024, Iran launched ∼300 drones and missiles at Israel, in an unprecedented attack. As most studies examine the effects of trauma months or years later, less is known about its effects days later. To fill this gap, this study gauged the population response, five days after the attack.
View Article and Find Full Text PDFTherapists perspectives on the Early Intervention after Rape study: a qualitative process evaluation of a randomized controlled trial.
Eur J Psychotraumatol
December 2025
Department of Health Sciences in Aalesund, Norwegian University of Science and Technology (NTNU), Aalesund, Norway.
: Early interventions using trauma-focused cognitive behavioural therapy have the potential to alleviate post-traumatic stress symptoms in individuals who have experienced recent sexual assault. Specialized Sexual Assault Centers (SACs) in Norway offers psychosocial support, however, this support varies across SACs and its efficacy has not been researched. The Early Intervention after Rape (EIR) study is a multisite randomized controlled trial designed to assess the efficacy and effectiveness of training SAC nurses and social workers to deliver a modified version of prolonged exposure therapy shortly after rape.
View Article and Find Full Text PDFSeverity-Dependent Long-Term Post-Traumatic Changes in the Circulating Oxylipin Profile.
Int J Mol Sci
December 2024
Research Laboratories and Clinic of Orthopedics, Trauma and Plastic Surgery, Leipzig University and University Hospital Leipzig, 04103 Leipzig, Germany.
Trauma causes the breakdown of membrane phospholipids and the subsequent degradation of the released polyunsaturated fatty acids (PUFAs) to partially bioactive oxylipins. Here, we screened for circulating PUFAs and oxylipins in patients (n = 34) differing from those of uninjured controls (n = 25) and analyzed their diagnostic potential. Patients were followed up for 1 to 240 h after minor/moderate, severe, and very severe injuries.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!