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Respiratory Pathology and Cardiovascular Diseases: A Scoping Review.
Open Respir Arch
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Translational Research In Airway Diseases Group (TRIAD), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Respiratory diseases and cardiovascular diseases (CVDs) have high prevalence and share common risk factors. In some respiratory diseases such as sleep apnoea and COPD, the evidence of their negative impact on the prognosis of CVDs seems clear. However, in other diseases it is less evident whether there is any direct relationship.
View Article and Find Full Text PDFDapagliflozin ameliorates Lafora disease phenotype in a zebrafish model.
Biomed Pharmacother
January 2025
IRCCS Stella Maris Foundation, Calambrone, via dei Giacinti 2, Pisa 56128, Italy.
Lafora disease (LD) is an ultra-rare and still incurable neurodegenerative condition. Although several therapeutic strategies are being explored, including gene therapy, there are currently no treatments that can alleviate the course of the disease and slow its progression. Recently, gliflozins, a series of SGLT2 transporter inhibitors approved for use in type 2 diabetes mellitus, heart failure and chronic kidney disease, have been proposed as possible repositioning drugs for the treatment of LD.
View Article and Find Full Text PDFThe controversial status of affect in the interplay between the body and the mind Comment on "The affective grounds of the mind. The affective pertinentization (APER) model" by S. Salvatore, A. Palmieri, R. De Luca Picione, V. Bochicchio, M. Reho, M. R. Serio, & G. Salvatore.
Phys Life Rev
December 2024
Department of Psychology, Catholic University of the Sacred Heart, Largo Gemelli 1, 20123 Milano, Italy. Electronic address:
Examining the Impact of a Brief Compassion Focused Intervention on Everyday Experiences of Compassion in Autistic Adults Through Psychophysiology and Experience Sampling.
Appl Psychophysiol Biofeedback
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Compassionate Mind Research Group, School of Psychology, University of Queensland, Brisbane, QLD, Australia.
Autistic adults experience greater rates of anxiety and depression compared to the general population. Compassion-focused therapy interventions, aimed at promoting self-compassion capabilities, have shown efficacy in improving mental health outcomes in autistic and non-autistic samples suffering from self-criticism that contribute to difficulties in emotion regulation. We explored the experiences of autistic adults during a brief one-week online self-compassion exercise to evaluate it's feasibility and acceptability through self-report, experience sampling, and parasympathetic activity measured via HRV.
View Article and Find Full Text PDF5,7-Dihydroxyflavone acts on eNOS to achieve hypotensive effects in spontaneously hypertensive rats.
Sci Rep
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Anatomy Department, College of Basic Medical Science, Xiamen Medical College, Xiamen, Fujian, China.
Hypertension is one of the most serious chronic diseases. This study will focus on the systemic antihypertensive mechanisms of 5,7-dihydroxyflavone from in silico simulations to in vivo validations. In-silico studies were applied by network pharmacology, molecular docking, and molecular dynamic simulation.
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