AI Article Synopsis
- Non-small cell lung cancer (NSCLC) is a prevalent and deadly lung cancer, with the study focusing on how genetic variations in the caspase 9 gene (CASP9) affect NSCLC risk.
- The research involved 96 NSCLC patients and 67 healthy controls, analyzing a specific CASP9 genetic variant using real-time PCR.
- Findings revealed that the GG genotype of CASP9 was more common in NSCLC patients, while the mutations GA and A were more frequent in controls, suggesting that GG is a risk factor and the A allele may reduce the risk of developing NSCLC.
Article Abstract
Background/aim: Non-small cell lung cancer (NSCLC) is one of the most common forms of lung cancer and the leading cause of cancer-related deaths in the world. Caspase 9 (CASP9) plays a central role in the intrinsic apoptotic pathway. The aim of the study was to investigate the role of caspase 9 gene polymorphism in patients with non-small cell lung cancer.
Materials And Methods: The study included 96 NSCLC cases and 67 controls. CASP9 Ex5+32 G>A polymorphism was investigated by real-time polymerase chain reaction.
Results: There was a significant difference between the groups in the frequency of CASP9 genotypes (p=0.008). The number of the carriers of the ancestral GG genotype, was significantly higher in the NSCLC group than in the control (p=0.009). The heterozygote GA genotype and mutant A allele frequency were significantly higher in the control group compared to the NSCLC group (p=0.005, p=0.009, respectively). Serum CASP9 levels were significantly lower in the patients group than in the control group (p<0.0001).
Conclusion: CASP9 Ex5+32 GG genotype was a risk factor whereas the variant A allele could be a risk-reducing factor for NSCLC.
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| http://dx.doi.org/10.21873/anticanres.13361 | DOI Listing |
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