Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment.

J Zhejiang Univ Sci B

The Breast Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Published: June 2019

Exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression. The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance. In this review, we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research. These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568217PMC
http://dx.doi.org/10.1631/jzus.B1900039DOI Listing

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