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Acitretin induced lung injury by differentiation syndrome.
Respir Med Case Rep
June 2020
Department of Rural Medicine - Pulmonary and Critical Care, Oklahoma State University College of Osteopathic Medicine, Tahlequah, OK, USA.
Differentiation syndrome is a life-threatening complication observed when retinoic acid is given to patients with acute promyelocytic leukemia. Retinoid compounds are also used in non-malignant conditions like psoriasis and it is rare to see differentiation syndrome in such settings. This reports details the clinical presentation and successful management of a patient with psoriasis who developed differentiation syndrome while on treatment with acitretin.
View Article and Find Full Text PDFAcitretin-induced differentiation syndrome in a case of generalized pustular psoriasis.
Indian J Dermatol Venereol Leprol
December 2020
Department of Dermatology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
Generalized edema has been reported to be a rare side effect of systemic retinoids. We report a patient who developed localized bipedal edema from acitretin. Other causes of bipedal edema were excluded and withdrawal of acitretin led to resolution of the edema.
View Article and Find Full Text PDFAcitretin : A Review of its Pharmacology and Therapeutic Use.
Drugs
April 1992
Adis International Limited, Private Bag 65901, 41 Centorian Drive, Mairangi Bay, Auckland 10, New Zealand.
Synopsis: Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar therapeutic index; i.e. a similar ratio of clinical efficacy to adverse effects.
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