AI Article Synopsis
- Brain-Derived Neurotrophic Factor (BDNF) is important for brain functions like synaptogenesis and synaptic plasticity, which are crucial in conditions like schizophrenia.
- This study compared BDNF levels in the blood of 95 individuals with schizophrenia and 80 healthy controls, focusing specifically on sex differences.
- Results showed that females with schizophrenia had higher BDNF levels compared to males with schizophrenia and healthy females, indicating that these differences could impact the way schizophrenia manifests in different sexes.
Article Abstract
Brain-Derived Neurotrophic Factor (BDNF) acts as a critical regulator of synaptogenesis and synaptic plasticity. Sex differences have been demonstrated in many aspects of schizophrenia. This study tested for sex-specific differences in peripheral BDNF levels in people with schizophrenia and healthy controls. We measured circulating plasma BDNF levels in 95 people with schizophrenia and 80 healthy controls. Plasma BDNF levels were significantly elevated in females with schizophrenia compared to males with schizophrenia and to female healthy controls. These results suggest that sex differences in peripheral BDNF levels may contribute to other sex related differences in schizophrenia.
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| http://dx.doi.org/10.1016/j.schres.2019.04.015 | DOI Listing |
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