Objective: To evaluate the frequency of anti-collagen type V in humans with early systemic sclerosis (SSc) compared to defined SSc patients and healthy controls, since collagen type V was shown to be overexpressed in early SSc patients' skin and there is no data concerning the presence of this antibody in early stages of human SSc. Experimental studies showed that animal models immunized with collagen type V developed a disease similar to human systemic sclerosis (SSc), with antibodies production, mainly in early stages post-immunization.
Methods: Eighty-one female SSc patients were included and divided into two groups: early-SSc (18 patients-EULAR Preliminary Criteria) and defined-SSc (63 patients-ACR Criteria 1980). The control group consisted of 19 healthy women age-matched to Early-SSc group. Anti-collagen type V was performed by ELISA. Data was analyzed by appropriate tests.
Results: The prevalence of anti-collagen type V in early-SSc, defined-SSc and control groups was respectively 33, 17 and 5% (p = 0.07). SSc patients with anti-collagen type V had shorter disease duration compared to those without this antibody (8.8 ± 5.1 vs. 14.7 ± 8.9, p = 0.006). Likewise, early-SSc patients with anti-collagen V also had a shorter disease duration than patients negative for this antibody (4.6 ± 2.2 vs. 9.7 ± 5.2, p = 0.04). No association with clinical subsets or scleroderma antibodies specificities was observed (p > 0.05).
Conclusion: The production of anti-collagen type V in SSc seems to be an early event independent of other antibodies specificities. Further studies are necessary to determine if the underlying mechanism for this chronology involves a primary immune response to abnormal expression of collagen type V.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1186/s42358-019-0063-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aire attenuate collagen-induced arthritis by suppressing T follicular helper cells through ICOSL.
Int Immunopharmacol
January 2025
Department of Intensive Care Medicine, The First Hospital of Jilin University, Department of Immunology, College of Basic Medical Sciences. Clinical Laboratory, The First Hospital of Jilin University, Changchun, China. Electronic address:
Objective: To assess the expression levels of autoimmune regulator (Aire) and inducible costimulator molecule ligand (ICOSL), as well as T follicular helper (Tfh) cell numbers in rheumatoid arthritis (RA) patients, and to explore their relationship with RA severity. We also aimed to investigate the effect of Aire on arthritis and its underlying mechanisms.
Methods: The expression levels of Aire, ICOSL, and Tfh cell numbers were measured in RA patients.
Precise Lubrication and Protection of Cartilage Damage by Targeting Hydrogel Microsphere.
Adv Mater
October 2024
Laboratory for Advanced Lubricating Materials, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China.
Osteoarthritis (OA) is a degenerative bone and joint disease characterized by decreased cartilage lubrication, leading to continuous wear and ultimately irreversible damage. This situation is particularly challenging for early-stage OA, as current bio-lubricants lack precise targeting for small inflammatory lesions. In this work, an antibody-mediated targeting hydrogel microspheres (HMS) is developed to precisely lubricate the local injury site of cartilage and prevent the progression of early OA.
View Article and Find Full Text PDFHistological characterization of pulp regeneration using decellularized human dental pulp and mesenchymal stem cells in a feline model.
Tissue Cell
October 2024
Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
Regenerative endodontics aims to restore pulp tissues, thus preserving the vitality of the tooth. One promising approach involves the utilization of decellularized human dental pulp (DHDP) as a scaffold repopulated with Wharton's Jelly mesenchymal stem cells (WJMSCs). This study aimed to regenerate pulp tissues using DHDP and WJMSCs following pulpectomy in mature canine teeth of a feline animal model and to investigate the histological features of the regenerated pulp.
View Article and Find Full Text PDFKDM4C represses liver fibrosis by regulating H3K9me3 methylation of ALKBH5 and m6A methylation of snail1 mRNA.
J Dig Dis
May 2024
Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Objective: We aimed to disclose the molecular mechanism of snail1 in liver fibrosis.
Methods: Carbon tetrachloride (CCl) was used to induce a liver fibrosis model in mice whereby serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were evaluated, and liver pathological alternations were assessed. Rat hepatic stellate cells (HSC-T6) were irritated with transforming growth factor (TGF)-β1, followed by assessment of cell viability and migration.
Elevated serum levels of anti-collagen type I antibodies in patients with spontaneous cervical artery dissection and ischemic stroke: a prospective multicenter study.
Front Immunol
June 2024
Department of Neurology, University Hospital Leipzig, Leipzig, Germany.
Article Synopsis
- - Researchers investigated the potential link between autoimmunity and spontaneous cervical artery dissection (sCAD) by analyzing anti-collagen type I antibodies in various patient groups, including those with sCAD, ischemic stroke, and healthy controls.
- - A total of 57 sCAD patients were studied alongside control groups, with findings showing that while sCAD patients had higher antibody levels compared to healthy subjects, they had lower levels than those with unrelated ischemic strokes.
- - The study concluded that elevated levels of anti-collagen type I antibodies in sCAD patients are not a direct trigger for the condition but may relate to the metabolism and turnover of collagen type I.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!