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Reply to the 'Comment on "Dynamics and rheology of vesicles under confined Poiseuille flow"' by G. Coupier and T. Podgorski, , 2024, , DOI: 10.1039/D3SM01679J.
Soft Matter
August 2024
Université Grenoble Alpes, CNRS, LIPhy, F-38000 Grenoble, France.
In this answer, we provide our arguments in support of the possibility to observe the single file-organization of red blood cells in microvessels and the resulting unexpectedly weak increase of blood viscosity with increasing hematocrit, the physiological relevance of which was questioned in the comment. The key element is that the equivalent diameter in 3D for the maximal hematocrit corresponding to a single file of red blood cells is about 10 µm and not 20 µm, as in 2D. In addition, the viscosity contrast (ratio between the cell internal and external viscosities) value must be chosen in our 2D simulation in a such a way that the effective viscosity (a linear combination of the internal, external and membrane viscosities) be close to that of a real RBC.
View Article and Find Full Text PDFComment on "Dynamics and rheology of vesicles under confined Poiseuille flow" by Z. Gou, H. Zhang, A. Nait-Ouhra, M. Abbasi, A. Farutin and C. Misbah, , 2023, , 9101.
Soft Matter
August 2024
Université Grenoble Alpes, CNRS, Grenoble INP, LRP, F-38000 Grenoble, France.
In a recent paper, [Gou , , 2023, , 9101-9114] studied numerically the viscosity of a confined suspension of vesicles flowing in a channel as a function of vesicle concentration. In order to discuss the genericity of the observed behaviour, namely a nearly constant effective viscosity at low concentrations, we complement their study by a comparison with the few existing ones in the literature. In particular, we highlight that they fail to reproduce well established results for blood viscosity in microcirculation, thereby suggesting that the conclusions regarding the optimization of cell transport and oxygenation may not apply.
View Article and Find Full Text PDFJanus Kinase Inhibitor Therapy and Risk of Age-Related Macular Degeneration in Autoimmune Disease.
JAMA Ophthalmol
August 2024
Genomics Research Center, AbbVie, North Chicago, Illinois.
Importance: The involvement of chronic inflammation in the pathogenesis of age-related macular degeneration (AMD) opens therapeutic possibilities to AMD management.
Objective: To determine whether Janus kinase inhibitors (JAKis) are associated with a reduced risk of AMD development in patients with autoimmune diseases.
Design, Setting, And Participants: This retrospective observational cohort study used administrative claims data from Merative MarketScan research databases (Commercial and Medicare Supplemental) and Optum Clinformatics Data Mart databases between January 1, 2010, and January 31, 2022.
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide.
JAMA Ophthalmol
August 2024
Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.
Importance: Anecdotal experience raised the possibility that semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA) with rapidly increasing use, is associated with nonarteritic anterior ischemic optic neuropathy (NAION).
Objective: To investigate whether there is an association between semaglutide and risk of NAION.
Design, Setting, And Participants: In a retrospective matched cohort study using data from a centralized data registry of patients evaluated by neuro-ophthalmologists at 1 academic institution from December 1, 2017, through November 30, 2023, a search for International Statistical Classification of Diseases and Related Health Problems, Tenth Revision code H47.
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